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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Incorporation of silver nanoparticles on Ti7.5Mo alloy surface containing TiO2 nanotubes arrays for promoting antibacterial coating - In vitro and in vivo study

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Rosifini Alves Clar, Ana Paula [1] ; Konatu, Reginaldo T. [1] ; do Amaral Escada, Ana Lucia [1] ; de Souza Nunes, Miriam Celi [2] ; Maurer-Morelli, Claudia Vianna [2] ; Dias-Netipanyj, Marcela Ferreira [3] ; Popat, Ketul C. [3] ; Mantovani, Diego [4]
Total Authors: 8
[1] Sao Paulo State Univ, Sch Engn, Mat & Technol Dept, UNESP, Guaratingueta, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Med Genet, Campinas, SP - Brazil
[3] Colorado State Univ, Dept Mech Engn, Sch Biomed Engn, Ft Collins, CO 80523 - USA
[4] Laval Univ, Met & Mat Engn, Dept Min, Quebec City, PQ - Canada
Total Affiliations: 4
Document type: Journal article
Source: Applied Surface Science; v. 455, p. 780-788, OCT 15 2018.
Web of Science Citations: 1

Bulk and surface properties are very important for materials used in biomedical applications. The development of new surface treatments, such as antibacterial coatings can directly affect the response of the surface. The purpose of this study was the development of antibacterial coating on the Ti7.5Mo alloy surface combining TiO2 nanotubes with silver nanoparticles incorporation using polydopamine assisted immobilization technique. Surface characterization analysis showed that silver nanoparticles were successfully immobilized. The concentration established was bactericidal, i.e., no bacteria grew after incubation. In vivo results showed that silver incorporation on the surface containing TiO2 nanotubes did not cause altered locomotor activity in zebrafish. On the other hand, it affected the cell adhesion on the surface. Thus, these results confirm the hypothesis that silver nanoparticles were totally incorporated to polydopamine on the surface containing TiO2 nanotubes and acted as the main mechanism the death of the bacteria by contact. (AU)

FAPESP's process: 14/15640-8 - Functional studies of genes of inflammation and microRNAs related to seizures using the zebrafish model
Grantee:Cláudia Vianna Maurer Morelli
Support type: Regular Research Grants
FAPESP's process: 13/08200-9 - Drug release study in TI-7.5Mo surface after TiO2 nanotubes growth
Grantee:Ana Lúcia Do Amaral Escada
Support type: Scholarships in Brazil - Post-Doctorate