Jaboticaba extract prevents prediabetes and liver steatosis in high-fat-fed aging mice

Author(s)

Lamas, C. A. ^[1] ; Lenquiste, S. A. ^[2] ; Baseggio, A. M. ^[2] ; Cuquetto-Leite, L. ^[1] ; Kido, L. A. ^[1] ; Aguiar, A. C. ^[3] ; Erbelin, M. N. ^[3] ; Collares-Buzato, C. B. ^[4] ; Marostica Jr, M. R. ; Cagnon, V. H. A. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Bertrand Russel Av, BR-13083865 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Dept Food & Nutr, 80 Monteiro Lobato St, BR-13083852 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Inst Chem, ThoMSon Mass Spectrometry Lab, BR-13083859 Campinas, SP - Brazil

^[4] Univ Estadual Campinas, Dept Biochem & Tissue Biol, 255 Monteiro Lobato St, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: Journal of Functional Foods; v. 47, p. 434-446, AUG 2018.
• Web of Science Citations: 5

Abstract

We developed a patented jaboticaba peel extract (PJE) aiming to investigate PJE dose-dependent effect in liver and metabolism of high-fat-fed aging mice. Male FVB mice were distributed as follows: YG(young; 3-monthsold), AG(aged; 11-months-old), HfAG(aged + high-fat diet), JAGI(aged + 2.9gPJE/Kg), JAGII(aged + 5.8gPJE/Kg), HfJAGI(aged + high-fat diet + 2.9gPJE/Kg) and HfJAGII(aged + high-fat diet + 5.8gPJE/Kg). PJE showed a potent antioxidant activity and high bioactive compounds content. Both PJE doses prevented weight gain, dyslipidemia, hyperglycemia, reduced COX-2 level and improved HDL-cholesterol, pIRS-1, and PPAR gamma levels in high-fat-fed aging mice. Only HfJAGII showed lower TNF alpha level, insulin resistance, and glucose intolerance relative to HfAG. Taking aging into consideration, PJE prevented dyslipidemia and hyperglycemia, reduced TNF alpha besides increasing pIRS-1 and PPAR gamma levels, and restoring the hepatic structure in aged mice. Thus, PJE anti-inflammatory, hypoglycemic and lipid modulation capacity prevented the pre-diabetes and NAFLD in this model, being indicated as potential therapy to prevent hepatic and metabolic disorders associated to obesity, diabetes, and aging. (AU)

• FAPESP's process: 15/25714-1 - Effects of jaboticaba peel extract therapy on the prostate biology and metabolic parameters of the mice FVB in relation to aging and hyperlipidic diet
• Grantee: Valéria Helena Alves Cagnon Quitete
• Support Opportunities: Regular Research Grants