Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke

Author(s):Show less -

Martins Lourenco, Maria Angelica ^[1] ; Braz, Mariana Gobbo ^[2] ; Aun, Aline Garcia ^[2] ; Buzati Pereira, Bruna Leticia ^[1] ; Figueiredo, Amanda Menezes ^[1] ; Candido da Silva, Renata Aparecida ^[1] ; Kazmarek, Elisa Moya ^[1] ; Correa Alegre, Patricia Helena ^[1] ; Bachiega, Tatiana Fernanda ^[1] ; Zanati, Silmeia Garcia ^[1] ; Azevedo, Paula Schmidt ^[1] ; Polegato, Bertha Furlan ^[1] ; Henrique Fernandes, Ana Angelica ^[3] ; Rupp de Paiva, Sergio Alberto ^[1] ; Mamede Zornoff, Leonardo Antonio ^[1] ; Minicucci, Marcos Ferreira ^[1]

Affiliation

^[1] UNESP Sao Paulo State Univ, Botucatu Med Sch, Internal Med Dept, Botucatu, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Botucatu Med Sch, Dept Anesthesiol, Botucatu, SP - Brazil

^[3] UNESP Sao Paulo State Univ, Botucatu Med Sch, Inst Biol Sci, Chem & Biochem Dept, Botucatu, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE; v. 22, n. 8, p. 3996-4004, AUG 2018.
• Web of Science Citations: 0

Abstract

The objective of this study was to investigate the influence of Spondias mombin (SM) supplementation on the cardiac remodelling process induced by exposure to tobacco smoke (ETS) in rats. Male Wistar rats were divided into 4 groups: group C (control, n = 20) comprised animals not exposed to cigarette smoke and received standard chow; group ETS (n = 20) comprised animals exposed to cigarette smoke and received standard chow; group ETS100 (n = 20) received standard chow supplemented with 100 mg/kg body weight/d of SM; and group ETS250 (n = 20) received standard chow supplemented with 250 mg/kg body weight/d of SM. The observation period was 2 months. The ETS animals had higher values of left cardiac chamber diameters and of left ventricular mass index. SM supplementation attenuated these changes. In addition, the myocyte cross-sectional area (CSA) was lower in group C compared with the ETS groups; however, the ETS250 group had lower values of CSA compared with the ETS group. The ETS group also showed higher cardiac levels of lipid hydroperoxide (LH) compared with group C; and, groups ETS100 and ETS250 had lower concentrations of LH compared with the ETS group. Regarding energy metabolism, SM supplementation decreased glycolysis and increased the -oxidation and the oxidative phosphorylation. There were no differences in the expression of Nrf-2, SIRT-1, NF-B, interferon-gamma and interleukin 10. In conclusion, our results suggest that ETS induced the cardiac remodelling process. In addition, SM supplementation attenuated this process, along with oxidative stress reduction and energy metabolism modulation. (AU)

• FAPESP's process: 14/21310-0 - Influence of caja supplementation on cardiac remodeling induced by cigarette smoke exposure in rats
• Grantee: Maria Angelica Martins Lourenço
• Support Opportunities: Scholarships in Brazil - Master