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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus)

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Campos, Monica S. [1] ; Ribeiro, Naiara C. S. [2] ; de Lima, Rodrigo F. [2] ; Santos, Mariana B. [3] ; Vilamaior, Patricia S. L. [1] ; Regasini, Luis O. [3] ; Biancardi, Manoel F. [2] ; Taboga, Sebastiao R. [1] ; Santos, Fernanda C. A. [2]
Total Authors: 9
[1] State Univ Sao Paulo UNESP, Dept Biol, Lab Microscopy & Microanal, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Fed Goias, Inst Biol Sci, Dept Histol Embryol & Cell Biol, Lab Microscopy Appl Reprod, BR-74001970 Goiania, Go - Brazil
[3] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci IBILCE, Dept Chem & Environm Sci, Lab Green & Med Chem, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REPRODUCTION FERTILITY AND DEVELOPMENT; v. 30, n. 9, p. 1180-1191, AUG 2018.
Web of Science Citations: 0

Chrysin is a bioflavonoid found in fruits, flowers, tea, honey and wine, which has antioxidant, anti-inflammatory, antiallergic and anticarcinogenic properties. This flavone has also been considered as beneficial for reproduction due its testosterone-boosting potential. Thus, the aim of this study was to evaluate the effects of chrysin on the prostate and gonads of male and female adult gerbils. In addition, a comparative analysis of the effects of testosterone on these same organs was conducted. Ninety-day-old male and female gerbils were treated with chrysin (50 mg kg(-1) day(-1)) or testosterone cypionate (1 mg kg(-1) week(-1)) for 21 days. The ventral male prostate and female prostate were dissected out for morphological, morphometric-stereological and ultrastructural assays. Testes and ovaries were submitted to morphological and morphometric-stereological analyses. Chrysin treatment caused epithelial hyperplasia and stromal remodelling of the ventral male and female prostate. Ultrastructurally, male and female prostatic epithelial cells in the chrysin group presented marked development of the organelles involved in the biosynthetic-secretory pathway, whereas cellular toxicity was observed only in female glands. Chrysin preserved normal testicular morphology and increased the number of growing ovarian follicles. Comparatively, testosterone treatment was detrimental to the prostate and gonads, since foci of prostatic intraepithelial neoplasia and gonadal degeneration were observed in both sexes. Thus, under the experimental conditions of this study, chrysin was better tolerated than testosterone in the prostate and gonads. (AU)

FAPESP's process: 14/18330-0 - Synthesis and biological evaluation of curcumin-cinnamaldehyde hybrids as bacterial cell division inhibitors
Grantee:Luis Octávio Regasini
Support type: Regular Research Grants