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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of lipids in the inception, maintenance and complications of dengue virus infection

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Odir Rodrigues Melo, Carlos Fernando [1] ; Delafiori, Jeany [1] ; Dabaja, Mohamad Ziad [1] ; de Oliveira, Diogo Noin [1] ; Guerreiro, Tatiane Melina [1] ; Colombo, Tatiana Elias [2] ; Nogueira, Mauricio Lacerda [2] ; Proenca-Modena, Jose Luiz [3] ; Catharino, Rodrigo Ramos [1]
Total Authors: 9
[1] Univ Estadual Campinas, Sch Pharmaceut Sci, INNOVARE Biomarkers Lab, Campinas, SP - Brazil
[2] Sao Jose Rio Preto FAMERP, Sch Med, Sao Jose Do Rio Preto - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut & Bioagents, Lab Study Emerging Viruses LEVE, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, AUG 7 2018.
Web of Science Citations: 3

Dengue fever is a viral condition that has become a recurrent issue for public health in tropical countries, common endemic areas. Although viral structure and composition have been widely studied, the infection phenotype in terms of small molecules remains poorly established. This contribution providing a comprehensive overview of the metabolic implications of the virus-host interaction using a lipidomic-based approach through direct-infusion high-resolution mass spectrometry. Our results provide further evidence that lipids are part of both the immune response upon Dengue virus infection and viral infection maintenance mechanism in the organism. Furthermore, the species described herein provide evidence that such lipids may be part of the mechanism that leads to blood-related complications such as hemorrhagic fever, the severe form of the disease. (AU)

FAPESP's process: 16/17066-2 - Metabolomics and lipidomics the Zika virus, from mosquitoes to the patient
Grantee:Carlos Fernando Odir Rodrigues Melo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018
Grantee:Maurício Lacerda Nogueira
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/06809-1 - Determination of chemical markers in various bovine products using mass spectrometry
Grantee:Rodrigo Ramos Catharino
Support type: Regular Research Grants
FAPESP's process: 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders
Grantee:Aníbal Eugênio Vercesi
Support type: Research Projects - Thematic Grants