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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

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Author(s):
Marchese, Leticia [1] ; Nascimento, Janaina de Freitas [1] ; Damasceno, Flavia Silva [1] ; Bringaud, Frederic [2] ; Michels, Paul A. M. [3, 4] ; Silber, Ariel Mariano [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Lab Biochem Tryps LaBTryps, Av Lineu Prestes 1374, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Bordeaux, Lab Microbiol Fondamentale & Pathogen MFP, CNRS, UMR 5234, 146 Rue Leo Saignat, Batiment 3A, F-33076 Bordeaux - France
[3] Univ Edinburgh, Ctr Immun Infect & Evolut, Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian - Scotland
[4] Univ Edinburgh, Ashworth Labs, Sch Biol Sci, Ctr Translat & Chem Biol, Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian - Scotland
Total Affiliations: 4
Document type: Review article
Source: PATHOGENS; v. 7, n. 2 JUN 2018.
Web of Science Citations: 7
Abstract

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts. (AU)

FAPESP's process: 16/06034-2 - The biological role of amino acids and their metabolites in Trypanosoma cruzi
Grantee:Ariel Mariano Silber
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/16553-0 - The role of the mitochondrial and glycosomal isoforms of fumarate reductase of Trypanosoma Cruzi
Grantee:Ariel Mariano Silber
Support Opportunities: Research Grants - Visiting Researcher Grant - International