Adapting to stress - chaperome networks in cancer

Author(s)

Joshi, Suhasini ^[1] ; Wang, Tai ^[1] ; Araujo, Thais L. S. ^[1] ; Sharma, Sahil ^[1] ; Brodsky, Jeffrey L. ^[2] ; Chiosis, Gabriela ^{[1, 3]}

Affiliation

^[1] Mem Sloan Kettering Canc Ctr, Chem Biol Program, 1275 York Ave, New York, NY 10021 - USA

^[2] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 - USA

^[3] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 - USA

• Document type: Review article
• Source: NATURE REVIEWS CANCER; v. 18, n. 9, p. 562-575, SEP 2018.
• Web of Science Citations: 21

Abstract

In this Opinion article, we aim to address how cells adapt to stress and the repercussions chronic stress has on cellular function. We consider acute and chronic stress-induced changes at the cellular level, with a focus on a regulator of cellular stress, the chaperome, which is a protein assembly that encompasses molecular chaperones, co-chaperones and other co-factors. We discuss how the chaperome takes on distinct functions under conditions of stress that are executed in ways that differ from the one-on-one cyclic, dynamic functions exhibited by distinct molecular chaperones. We argue that through the formation of multimeric stable chaperome complexes, a state of chaperome hyperconnectivity, or networking, is gained. The role of these chaperome networks is to act as multimolecular scaffolds, a particularly important function in cancer, where they increase the efficacy and functional diversity of several cellular processes. We predict that these concepts will change how we develop and implement drugs targeting the chaperome to treat cancer. (AU)

• FAPESP's process: 17/01130-6 - Mechanisms and implications of selective cell-surface Grp94 inhibition in breast cancer cells
• Grantee: Thaís Larissa Araujo de Oliveira Silva
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor