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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The human papillomavirus (HPV)-related cancer biology: An overview

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Author(s):
Araldi, Rodrigo Pinheiro [1] ; Sant'Ana, Thalita Araujo [2] ; Modolo, Diego Grando [2] ; de Melo, Thatiana Correa [3] ; Spadacci-Morena, Diva Denelle [4] ; Stocco, Rita de Cassia [2] ; Cerutti, Janete Maria [1] ; de Souza, Edislane Barreiros [5]
Total Authors: 8
Affiliation:
[1] Sao Paulo Fed Univ UNIFESP, Genet Basis Thyroid Canc Lab, Sao Paulo, SP - Brazil
[2] Butantan Inst, Genet Lab, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Med Sch, Haematol & Mol Biol Lab, Sao Paulo, SP - Brazil
[4] Butantan Inst, Pathophysiol Lab, Sao Paulo, SP - Brazil
[5] Sao Paulo State Univ UNESP, Fac Sci & Languages, Biotechnol Dept, Genet Lab, BR-19806900 Assis, SP - Brazil
Total Affiliations: 5
Document type: Review article
Source: BIOMEDICINE & PHARMACOTHERAPY; v. 106, p. 1537-1556, OCT 2018.
Web of Science Citations: 6
Abstract

Despite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20-25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agentrelated cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies. (AU)

FAPESP's process: 17/14948-7 - Study of LIMD2 role on thyroid cancer epithelial-mesenchymal transition
Grantee:Rodrigo Pinheiro Araldi
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/20617-5 - Study of the action of bovine papillomavirus (BPV) in epithelial-mesenchymal transition
Grantee:Rodrigo Pinheiro Araldi
Support Opportunities: Scholarships in Brazil - Doctorate