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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thyroid hormone actions on male reproductive system of teleost fish

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Author(s):
Tovo-Neto, Aldo [1, 2, 3] ; Rodrigues, Maira da Silva [2, 3] ; Habibi, Hamid R. [1, 4] ; Nobrega, Rafael Henrique [3]
Total Authors: 4
Affiliation:
[1] Univ Calgary, Dept Biol Sci, Calgary, AB - Canada
[2] Sao Paulo State Univ, UNESP, Aquaculture Program, Jaboticabal, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Reprod & Mol Biol Grp, Dept Morphol, Botucatu, SP - Brazil
[4] Univ Calgary, Physiol & Pharmacol, Calgary, AB - Canada
Total Affiliations: 4
Document type: Journal article
Source: General and Comparative Endocrinology; v. 265, n. SI, p. 230-236, SEP 1 2018.
Web of Science Citations: 7
Abstract

Thyroid hormones (THs) play important roles in the regulation of many biological processes of vertebrates, such as growth, metabolism, morphogenesis and reproduction. An increasing number of studies have been focused on the involvement of THs in the male reproductive system of vertebrates, in particular of fish. Therefore, this mini-review aims to summarize the main findings on THs role in male reproductive system of fish, focusing on sex differentiation, testicular development and spermatogenesis. The existing data in the literature have demonstrated that THs exert their roles at the different levels of the hypothalamic-pituitary-gonadal (HPG) axis. In general a positive correlation has been shown between THs and fish reproductive status; where THs are associated with testicular development, growth and maturation. Recently, the molecular mechanisms underlying the role of THs in spermatogenesis have been unraveled in zebrafish testis. THs promote germ cell proliferation and differentiation by increasing a stimulatory growth factor of spermatogenesis produced by Sertoli cells. In addition, THs enhanced the gonadotropin-induced androgen release in zebrafish testis. Next to their functions in the adult testis, THs are involved in the gonadal sex differentiation through modulating sex-related gene expression, and testicular development via regulation of Sertoli cell proliferation. In conclusion, this mini-review showed that THs modulate the male reproductive system during the different life stages of fish. The physiological and molecular mechanisms showed a link between the thyroid and reproduction, suggesting a possibly co-evolution and interdependence of these two systems. (AU)

FAPESP's process: 17/15793-7 - Effects of hypothyroidism on testicular function of Danio rerio and relation between thyroid hormones and follicle stimulating hormone (Fsh)
Grantee:Maira da Silva Rodrigues
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/07620-7 - Spermatogonial stem cell bank to preserve the genotype of endangered and valuable teleost species
Grantee:Rafael Henrique Nóbrega
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 17/09218-0 - Effects of methimazole-induced thyroid hormone insufficiency on zebrafish (Danio rerio) spermatogenesis
Grantee:Aldo Tovo Neto
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/16280-5 - Molecular and endocrine control involved on gonadal differentiation of zebrafish (Danio rerio)
Grantee:Aldo Tovo Neto
Support type: Scholarships in Brazil - Doctorate