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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?

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Author(s):
Scorzoni, Liliana [1] ; Alves de Paula e Silva, Ana Carolina [1] ; de Oliveira, Haroldo Cesar [1] ; Marcos, Caroline Maria [1] ; Singulani, Junya de Lacorte [1] ; Fusco-Almeida, Ana Marisa [1] ; Soares Mendes-Giannini, Maria Jose [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista UNESP, Lab Micol Clin, Dept Anal Clin, Fac Ciencias Farmaceut, Araraquara - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Medical Mycology; v. 56, n. 3, p. 374-377, APR 2018.
Web of Science Citations: 2
Abstract

Paracoccidioidomycosis (PCM) is a fungal disease restricted to Latin countries, and its etiologic agents derive from the Paracoccidioides genus. Attenuation or loss of virulence in Paracoccidioides spp. following successive subculturing has been described. However, virulence can be recovered by passage in mammalian host. In this study, the recovery of adhesion of P. brasiliensis through passage in mice was compared to that in the insect Galleria mellonella. Analysis of in vitro fungal-host cell interaction, gene expression of adhesins, and analysis of the survival curves revealed that Galleria mellonella is useful for the reactivation of P. brasiliensis adhesion. (AU)

FAPESP's process: 14/10446-9 - Evaluation of new therapies and biomarkers in paracoccidioidomycosis: antifungal activity of alkyl gallates in alternative models and mice and identification of circulating microRNAs
Grantee:Junya de Lacorte Singulani
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/10917-9 - Alternative animal models: Virulence of different phylogenetic species of Paracoccidioides and effect of the 30kDa 43kDa protein and their antibodies
Grantee:Liliana Scorzoni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/17048-4 - Two-component signal transduction (TCST) system as a new target for the treatment of paracoccidioidomycosis
Grantee:Caroline Maria Marcos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/03700-9 - Alternative animal as a model to study Paracoccidioides- host interaction: virulence, efficacy and toxicology of antifungal compounds and new preventive treatments
Grantee:Maria José Soares Mendes Giannini
Support type: Regular Research Grants
FAPESP's process: 15/14023-8 - Use of peptides with anti-adhesive activity in Paracoccidoides spp. in the treatment and prophylaxis of the paracoccidioidomycosis
Grantee:Haroldo Cesar de Oliveira
Support type: Scholarships in Brazil - Post-Doctorate