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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photobiomodulation induces antinociception, recovers structural aspects and regulates mitochondrial homeostasis in peripheral nerve of diabetic mice

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Author(s):
da Silva Oliveira, Victoria R. [1] ; Cury, Diego P. [2] ; Yamashita, Laura B. [1] ; Esteca, Marcos V. [3] ; Watanabe, Ii-Sei [2] ; Bergmann, Yoko Fee [1] ; Toniolo, Elaine F. [1, 4] ; Dale, Camila S. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Dept Anat, Lab Neuromodulat Expt Pain, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Anat, Lab Ultrastruct Cells & Tissues, Sao Paulo - Brazil
[3] Univ Estadual Campinas, Fac Sci Appl, Lab Cellular & Tissue Biol, Limeira - Brazil
[4] Univ City Sao Paulo, Med Sch, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Biophotonics; v. 11, n. 9 SEP 2018.
Web of Science Citations: 1
Abstract

Diabetic peripheral neuropathy (DPN) is a nervous disorder caused by diabetes mellitus, affecting about 50% of patients in clinical medicine. Chronic pain is one of the major and most unpleasant symptoms developed by those patients, and conventional available treatments for the neuropathy, including the associated pain, are still unsatisfactory and benefit only a small number of patients. Photobiomodulation (PBM) has been gaining clinical acceptance once it is able to promote early nerve regeneration resulting in significant improvement in peripheral nerves disabilities. In this work, the effects of PBM (660 nm, 30 mW, 1.6 J/cm(2), 0.28 cm(2), 15 s in a continuous frequency) on treating DPN-induced pain and nerve damage were evaluated in an experimental model of diabetic-neuropathy induced by streptozotocin in mice. PBM-induced antinociception in neuropathic-pain mice was dependent on central opioids release. After 21 consecutive applications, PBM increased nerve growth factor levels and induced structural recovery increasing mitochondrial content and regulating Parkin in the sciatic nerve of DPN-mice. Taking together, these data provide new insights into the mechanisms involved in the effects of PBM-therapy emphasizing its therapeutic potential in the treatment of DPN. (AU)

FAPESP's process: 16/10372-0 - Study of molecular mechanisms involved in low level laser therapy: induced analgesia in experimental diabetic peripheral neuropathy
Grantee:Victória Regina da Silva Oliveira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/17136-8 - Study of the molecular mechanisms involved in the low level laser therapy-induced antinociception in experimental diabetic neuropathy
Grantee:Camila Squarzoni Dale
Support Opportunities: Regular Research Grants
FAPESP's process: 14/03270-1 - The effect of low level laser therapy on peripheral neuropathy induced by Diabetes Mellitus in mice
Grantee:Laura Basilio Yamashita
Support Opportunities: Scholarships in Brazil - Scientific Initiation