Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zinc Alleviates Lipopolysaccharide Interference with Both Body Temperature and Sickness Behavior in Virgin Female Rats

Full text
Author(s):
Nascimento, Amanda Fiorentina [1] ; Kirychuk, Shelley [2] ; Bernardi, Maria Martha [3] ; Felicio, Luciano F. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, Sao Paulo - Brazil
[2] Univ Saskatchewan, Dept Med, CCHSA, Saskatoon, SK - Canada
[3] Univ Paulista, Program Environm & Expt Pathol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NEUROIMMUNOMODULATION; v. 25, n. 2, p. 89-95, 2018.
Web of Science Citations: 0
Abstract

Objectives: Previous studies from our group showed that Lipopolysaccharide (LPS) exposure induces several signs of sickness behavior, including a decrease in food consumption, body weight gain, adipsia, and a biphasic effect in tympanic temperature with a first phase of hypothermia, followed by an increased tympanic temperature. LPS can activate a chain of nonspecific host responses, including the immune response, and decreased zinc levels. In addition, there are differences in the immune response between males and females, particularly fever, with sex hormones interfering with body temperature. This study aims to characterize the effects of zinc treatment on tympanic temperature, body weight gain, food and water consumption, and general activity in open field of virgin female rats exposed to a dose of LPS that was previously reported to induce sickness behavior. Methods: Virgin female Wistar rats were treated with either saline (5) or LPS. One hour later, the S group received another injection of saline (S + S group), half of the LPS group received saline (LPS + S group) and the other half received zinc (LPS + Zn group). Tympanic temperature, body weight, and water and food consumption were measured for 96 h. Measurements and observations started 2 h after LPS administration. Results: Treatment with zinc attenuated LPS-increased temperature, decreased the body weight gain and food consumption, and water consumption was increased. Conclusion: Zinc treatment is beneficial as it reduces the increased tympanic temperature induced by LPS, but it does not influence other sickness behavior caused by exposure to LPS. (C) 2018 S. Karger AG, Basel (AU)

FAPESP's process: 09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships
Grantee:João Palermo Neto
Support Opportunities: Research Projects - Thematic Grants