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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Morphological and Cellular Characterization of the Fetal Canine (Canis lupus familiaris) Subventricular Zone, Rostral Migratory Stream, and Olfactory Bulb

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Author(s):
Orechio, Dailiany [1] ; Aguiar, Bruna Andrade [1] ; Diniz, Giovanne Baroni [2] ; Bittencourt, Jackson Cioni [2] ; Haemmerle, Carlos A. S. [2, 3] ; Watanabe, Ii-Sei [2] ; Miglino, Maria Angelica [1] ; Castelucci, Patricia [2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Vet Med & Zootechny, Dept Surg, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Ave Prof Dr Lineu Prestes 2415, BR-05508900 Sao Paulo - Brazil
[3] Univ Fed Parana, Sect Biol Sci, Dept Anat, Curitiba, Parana - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology; v. 301, n. 9, SI, p. 1570-1584, SEP 2018.
Web of Science Citations: 0
Abstract

The existence of neurogenesis in the adult brain is a widely recognized phenomenon, occurring in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the dentate gyrus in several vertebrate species. Neural precursors originated in the SVZ migrate to the main olfactory bulb (MOB), originating the rostral migratory stream (RMS) in the process. To better understand the formation of the adult neurogenic niches in dogs, we investigated the cellular composition and morphological organization of these areas in 57 days-old dog fetuses. Using multiple immunohistochemical markers, we demonstrated that the SVZ in the canine fetus is remarkably similar to the adult SVZ, with glial GFAP-immunoreactive (-ir) cells, DCX-ir neuroblasts and SOX2-ir neuronal progenitors tangentially organized along the dorsal lateral ventricle. The fetal RMS has all the features of its adult counterpart and closely resembles the RMS of other mammalian species. The late-development canine MOB has most of the neurochemical features of the adult MOB, including an early-developed TH-ir population and maturing CALR-ir interneurons, but CALB-ir neurons in the granule cell layer will only appear in the post-partum period. Taken together, our results suggest that the canine fetal development of adult neurogenic niches closely resembles those of primates, and dogs may be suitable models of human adult neurogenesis. Anat Rec, 301:1570-1584, 2018. (c) 2018 Wiley Periodicals, Inc. (AU)

FAPESP's process: 16/02748-0 - Study of the anatomical basis for a volume transmission mechanism on the Melanin Concentrating Hormone [MCH] peptidergic system
Grantee:Giovanne Baroni Diniz
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/25927-2 - Morphological, molecular and functional aspects of the interaction between the P2X7 receptor and pannexin-1 in the enteric glial cells following intestinal ischemia/reperfusion
Grantee:Patricia Castelucci
Support type: Regular Research Grants
FAPESP's process: 10/52068-0 - The putative envolvement of melanin-concentrating hormone in the control of lactation
Grantee:Jackson Cioni Bittencourt
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/02224-1 - The existence of neurogenesis during the lactation period
Grantee:Jackson Cioni Bittencourt
Support type: Research Projects - Thematic Grants