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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of the leaching of florfenicol from coated medicated fish feed into water

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Barreto, Fabiola M. [1] ; da Silva, Mariana R. [1] ; Braga, Patricia A. C. [1] ; Bragotto, Adriana P. A. [1] ; Hisano, Hamilton [2] ; Reyes, Felix G. R. [1]
Total Authors: 6
[1] Univ Estadual Campinas, Dept Food Sci, Sch Food Engn, UNICAMP, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil
[2] Embrapa Meio Ambiente, Rodovia SP-340, Km 127-5, POB 69, BR-13918110 Jaguariuna, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Environmental Pollution; v. 242, n. B, p. 1245-1252, NOV 2018.
Web of Science Citations: 1

Florfenicol is one of the most-used antimicrobial agents in global fish farming. Nevertheless, in most countries, its use is not conducted in accordance with good practices. The aim of this work was to evaluate the leaching of florfenicol from coated fish feed into the water. Analytical methods were developed and validated for the quantitation of florfenicol in medicated feed and water by UHPLC-MS/MS. Florfenicol residues in the water were quantified after 5- and 15-min exposures of the medicated feed in the water at 22 and 28 degrees C and at pH 4.5 and 8.0. The influence of pellet size and three coating agents (vegetable oil, carboxymethylcellulose, and low-methoxylated pectin) on the leaching of the drug was also assessed. Pellet size, coating agent, water temperature, and time of exposure significantly (p < 0.05) affected florfenicol leaching, while water pH did not interfere with the leaching. Coating with vegetable oil was the most efficient method to reduce florfenicol leaching, while coating with carboxymethylcellulose presented the highest leaching (approximately 60% after 15 min at 28 degrees C). Thus, the coating agent has a significant effect on the florfenicol leaching rate and, consequently, on the necessary dose of the drug to be administered. Moreover, it is worth mentioning that higher florfenicol leaching will pose a greater risk to environmental health, specifically in terms of the development of bacteria resistant to florfenicol. Additional studies are needed with other polymers and veterinary drugs used in medicated feed for fish farming. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/50452-5 - Veterinary drugs: development and validation of bioanalytical methods using LC-MS/MS and MALDI-TOF-MS and its applications in sanitary surveillance and the development of fish farming in Brazil
Grantee:Felix Guillermo Reyes Reyes
Support type: Research Grants - Research Partnership for Technological Innovation - PITE