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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling

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Acevedo-Rodriguez, A. [1, 2] ; Kauffman, A. S. [3] ; Cherrington, B. D. [4] ; Borges, C. S. [5] ; Roepke, T. A. [6] ; Laconi, M. [7, 8, 9]
Total Authors: 6
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 - USA
[2] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 - USA
[3] Univ Calif San Diego, Dept Reprod Med, La Jolla, CA 92093 - USA
[4] Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 - USA
[5] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
[6] Rutgers State Univ, Sch Environm & Biol Sci, Dept Anim Sci, New Brunswick, NJ - USA
[7] Univ Juan Agustin Maza, Lab Fisiopatol Ovar, Inst Med Biol Expt Cuyo IMBECU, CONICET, Mendoza - Argentina
[8] Univ Juan Agustin Maza, Fac Ciencias Vet & Ambient, Mendoza - Argentina
[9] Univ Mendoza, Fac Ciencias Med, Mendoza - Argentina
Total Affiliations: 9
Document type: Review article
Source: Journal of Neuroendocrinology; v. 30, n. 10, SI OCT 2018.
Web of Science Citations: 6

Reproduction and fertility are regulated via hormones of the hypothalamic-pituitary-gonadal (HPG) axis. Control of this reproductive axis occurs at all levels, including the brain and pituitary, and allows for the promotion or inhibition of gonadal sex steroid secretion and function. In addition to guiding proper gonadal development and function, gonadal sex steroids also act in negative- and positive-feedback loops to regulate reproductive circuitry in the brain, including kisspeptin neurones, thereby modulating overall HPG axis status. Additional regulation is also provided by sex steroids made within the brain, including neuroprogestins. Furthermore, because reproduction and survival need to be coordinated and balanced, the HPG axis is able to modulate (and be modulated by) stress hormone signalling, including cortiscosterone, from the hypothalamic-pituitary-adrenal (HPA) axis. This review covers recent data related to the neural, hormonal and stress regulation of the HPG axis and emerging interactions between the HPG and HPA axes, focusing on actions at the level of the brain and pituitary. (AU)

FAPESP's process: 12/25350-1 - Effects of in utero betamethasone exposure on male rats reproductive parameters, with emphasis on sperm quality and fertility: a multigenerational approach
Grantee:Cibele dos Santos Borges
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/13660-1 - Effects of in utero exposure to betamethasone on puberty instalation and reproductive parameters of Female Wistar rats
Grantee:Tainá Louise Pacheco
Support type: Scholarships in Brazil - Scientific Initiation