Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Developmental programming of the female neuroendocrine system by steroids

Full text
Adriana Abruzzese, Giselle [1] ; Crisosto, Nicolas [2, 3] ; Kempinas, Wilma De Grava [4] ; Sotomayor-Zarate, Ramon [5]
Total Authors: 4
[1] Univ Buenos Aires, Lab Fisiopatol Ovar, Ctr Estudios Farmacol & Botanicos CEFYBO, Consejo Nacl Invest Cient & Tecn CONICET, Fac Med, Paraguay 2155, C1121ABG, Buenos Aires, DF - Argentina
[2] Univ Chile, Sch Med, Endocrinol & Metab Lab, West Div, Santiago - Chile
[3] Clin Las Condes, Endocrinol Unit, Santiago - Chile
[4] Univ Estadual Paulista UNESP, Lab Reprod & Dev Biol & Toxicol, Dept Morphol, Inst Biosci, Botucatu, SP - Brazil
[5] Univ Valparaiso, Lab Neuroquim & Neurofarmacol, Ctr Neurobiol & Fisiopatol Integrativa, Inst Fisiol, Fac Ciencias, Valparaiso - Chile
Total Affiliations: 5
Document type: Review article
Source: Journal of Neuroendocrinology; v. 30, n. 10, SI OCT 2018.
Web of Science Citations: 1

Developmental programming refers to processes that occur during early life that may have long-term consequences, modulating adult health and disease. Complex diseases, such as diabetes, cancer and cardiovascular disease, have a high prevalence in different populations, are multifactorial, and may have a strong environmental component. The environment interacts with organisms, affecting their behaviour, morphology and physiology. This interaction may induce permanent or long-term changes, and organisms may be more susceptible to environmental factors during certain developmental stages, such as the prenatal and early postnatal periods. Several factors have been identified as responsible for inducing the reprogramming of various reproductive and nonreproductive tissues. Among them, both natural and synthetic steroids, such as endocrine disruptors, are known to have either detrimental or positive effects on organisms depending on the dose of exposure, stage of development and biological sexual background. The present review focuses on the action of steroids and endocrine disruptors as agents involved in developmental programming and on their modulation and effects on female neuroendocrine functions. (AU)

FAPESP's process: 12/25350-1 - Effects of in utero betamethasone exposure on male rats reproductive parameters, with emphasis on sperm quality and fertility: a multigenerational approach
Grantee:Cibele dos Santos Borges
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/13660-1 - Effects of in utero exposure to betamethasone on puberty instalation and reproductive parameters of Female Wistar rats
Grantee:Tainá Louise Pacheco
Support type: Scholarships in Brazil - Scientific Initiation