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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biofilm formed from a tri-ureasil organic-inorganic hybrid gel for use as a cubebin release system

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de Jesus, Natana A. M. [1] ; de Oliveira, Anna H. P. [1] ; Tavares, Denise C. [1] ; Furtado, Ricardo A. [1] ; de Silva, Marcio L. A. [1] ; Cunha, Wilson R. [1] ; Molina, Eduardo F. [1]
Total Authors: 7
[1] Univ Franca, Ave Dr Armando Salles Oliveira 201, BR-14404600 Franca, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Sol-Gel Science and Technology; v. 88, n. 1, p. 192-201, OCT 2018.
Web of Science Citations: 0

In this work, we report the effects of catalyst amount on a tri-ureasil hybrid gel prepared by the sol-gel route, with the aim of controlling the film-forming time. Investigation of the key properties of biofilms produced from the hybrid gels revealed that varying the amount of acid catalyst could tune the film-forming time, without changing the structural features of the thin and transparent films. Independent of catalyst amount, springthe films presented low toxicity towards cells, indicating their suitability for use as new transdermal drug delivery systems. Due to the hydrophobic nature of the polyoxypropylene (PPO polyether chains) present in the hybrid films, very low water uptake was observed. This characteristic could be advantageous, since materials that show high swelling behavior can cause inflammatory responses in cells. The hybrid film with incorporation of a bioactive agent (cubebin, isolated from Piper cubeba seeds) was evaluated as a drug delivery system. Release of the drug from the matrix displayed a two-step pattern, kinetically controlled by (i) slow diffusion of cubebin molecules, and (ii) fast diffusive mass transport created by the solute-solvent interaction. The release of cubebin from the tri-ureasil hybrid film could be employed for radical scavenging and for the treatment of diseases such as cancer, leishmaniasis, and trypanosomiasis. {[}GRAPHICS] . HighlightsTri-ureasil hybrid presents the film-forming properties in the fabrication of highly functional materials.The biofilms showed remarkable hydrophobicity, transparency, flexibility, and easy processability.The correlation between swelling assays and the wettability of the surface revealed key aspects of the release of a bioactive lignin.Hybrid biofilms could be useful for trypanocidal, analgesic, anti-inflammatory, antimutagenic, and chemotherapeutic purposes.A promising new platform for biofilm formation and as a vehicle for transdermal drug delivery system. (AU)

FAPESP's process: 13/20455-2 - Nanostructured organic-inorganic hybrids for controlled lignans release with pharmacological potential
Grantee:Eduardo Ferreira Molina
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 14/18876-2 - Evaluation of organic-inorganic hybrid matrices as film formers for lignans controlled release through transdermal route
Grantee:Natana Aparecida Martins de Jesus
Support type: Scholarships in Brazil - Scientific Initiation