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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mice Selected for Acute Inflammation Present Altered Immune Response during Pristane-Induced Arthritis Progression

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Correa, Mara A. [1] ; Borrego, Andrea [1] ; Jensen, Jose R. [1] ; Cabrera, Wafa H. K. [1] ; Barros, Michele [2] ; Katz, Iana S. S. [3] ; Canhamero, Tatiane [1] ; Spadafora-Ferreira, Monica [1] ; Fernandes, Jussara G. [1] ; Starobinas, Nancy [1] ; Ribeiro, Orlando G. [1] ; Ibanez, Olga M. [1] ; De Franco, Marcelo [1, 3]
Total Authors: 13
[1] Inst Butantan, Lab Imunogenit, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Lab Imunol Expt, Sao Paulo - Brazil
[3] Inst Pasteur, Secao Diagnost, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 0

Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltration of lymphocytes, as well as monocytes/macrophages and neutrophils, producing higher levels of IL-1 beta, IFN-gamma, TNF-alpha, IL-10, total IgG3, and chemokines. Resistant AIRmin mice controlled cell activation more efficiently than the AIRmax during arthritis progression. The weight alterations of the spleen and thymus in the course of PIA were observed. Our data suggest that selected AIRmax cellular and genetic immune mechanisms contribute to cartilage damage and arthritis severity, evidencing many targets for therapeutic actions. (AU)

FAPESP's process: 14/18060-2 - Research of genes regulating the severity of acute inflammation and their interactions with micro RNAs in the development of experimental arthritis
Grantee:Marcelo de Franco
Support type: Regular Research Grants