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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The hygiene hypothesis at a glance: Early exposures, immune mechanism and novel therapies

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Alexandre-Silva, Gabriel M. [1] ; Brito-Souza, Pablo A. [1] ; Oliveira, Ana C. S. [1] ; Cerni, Felipe A. [2] ; Zottich, Umberto [1] ; Pucca, Manuela B. [1]
Total Authors: 6
[1] Univ Fed Roraima, Med Sch, Boa Vista, RR - Brazil
[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Acta Tropica; v. 188, p. 16-26, DEC 2018.
Web of Science Citations: 5

The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its mechanism still remains with relevant controversies. Some studies defend that early exposures during childhood to microbes and parasites are key determinants to prevent allergies and autoimmune diseases; however, other studies demonstrated that these early exposures can even potentiate the clinical scenario of the diseases. Based on several studies covering the influences of microbiome, parasites, related theories and others, this review focuses on recent advances in the hygiene hypothesis field. In addition, the main immunological mechanisms underlying the hygiene hypothesis are also discussed. We also strongly encourage that researchers do not consider the hygiene hypothesis as a theory based strictly on hygiene habits, but a theory combining diverse influences, as illustrated in this review as the hygiene hypothesis net. (AU)

FAPESP's process: 17/14035-1 - Improving of human fragment antibodies (scFvs) specific for animals' venoms
Grantee:Felipe Augusto Cerni
Support type: Scholarships in Brazil - Post-Doctorate