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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum

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Author(s):
Clementino, Leandro da Costa [1] ; Arenas Velasquez, Angela Maria [1] ; Passalacqua, Thais Gaban [1] ; de Almeida, Leticia [1] ; Graminha, Marcia A. S. [2] ; Martins, Gilmarcio Z. [3] ; Salgueiro, Ligia [4] ; Cavaleiro, Carlos [4] ; Sousa, Maria do Ceu [4] ; Moreira, Raquel R. D. [5]
Total Authors: 10
Affiliation:
[1] Univ Estadual Paulista, UNESP, Inst Quim, Programa Posgrad Biotecnol, Araraquara, SP - Brazil
[2] Univ Estadual, UNESP, Fac Ciencias Farmaceut, Dept Anal Clin, Araraquara, SP - Brazil
[3] Ctr Univ Fundacao Educ Barretos, Barretos, SP - Brazil
[4] Univ Coimbra, Fac Farm, Coimbra - Portugal
[5] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Dept Principios Ativos & Nat, Araraquara, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 28, n. 6, p. 673-677, NOV-DEC 2018.
Web of Science Citations: 0
Abstract

ABSTRACT Leishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including difficult route of administration and toxicity, which turn the search for new therapeutic alternatives necessary. Herein, we evaluated the leishmanicidal in vitro activity of the solanum extract from Solanum lycocarpum A. St.-Hil., Solanaceae, and the isolated alkaloids solasodine, solamargine and solasonine against promastigotes and intracellular amastigotes of L. infantum. Solasodine (IC50-pro = 4.7 µg/ml; IC50-ama = 10.8 µg/ml) and solamargine (IC50-pro = 8.1 µg/ml; IC50-ama = 3.0 µg/ml) exhibited interesting leishmanicidal ativity. Solasonine was approximately four-times (Selective Index 3.7) more selective to the parasite than to the host cells. This data suggest that solasonine might be considered as a potential drug candidate for leishmaniasis treatment. (AU)

FAPESP's process: 17/03552-5 - Leishmaniasis: from screening to the study of mechanisms of action, a contribution to the discovery of new bioactive molecules
Grantee:Marcia Aparecida Silva Graminha
Support Opportunities: Regular Research Grants