| Full text | |
| Author(s): |
Holanda, Bruno B. C.
[1]
;
Alarcon, Rafael T.
[1]
;
Guerra, Renan B.
[1]
;
Rinaldo, Daniel
[1]
;
Spazzini, Fabiola C. R.
[1]
;
Castro, Ricardo A. E.
[2]
;
Bannach, Gilbert
[1]
Total Authors: 7
|
| Affiliation: | [1] UNESP Sao Paulo State Univ, Sch Sci, Chem Dept, BR-17033260 Bauru, SP - Brazil
[2] Coimbra Univ, Coll Pharm, P-3000578 Coimbra - Portugal
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS; v. 135, p. 76-84, OCT 2018. |
| Web of Science Citations: | 3 |
| Abstract | |
In this work, the thermal decomposition of mebendazole (MBZ) was studied to elucidate divergent data found in the literature concerning the thermal behavior of this drug. To this end, thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), evolved gas analysis (EGA), and DSC-photovisual analysis were employed to fully evaluate the polymorphic form A of MBZ. Our results showed that mebendazole undergoes mass loss starting at 205 degrees C with the release of methanol and carbon monoxide. Characterization of the main thermal decomposition product of MBZ through mid-infrared spectroscopy (MIR), proton nuclear magnetic resonance (H-1 NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and powder X-ray diffraction (PXRD) indicated the formation of 2-amino-5-benzoylbenzimidazole (MBZ-A). Kinetic parameters for MBZ and MBZ-A were also evaluated and shown herein. (AU) | |
| FAPESP's process: | 18/03460-6 - Structural modification of triglycerides aiming new monomers and polymers, using different synthetic routes: microwave irradiation and photopolymerization |
| Grantee: | Rafael Turra Alarcon |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/08820-8 - Synthesis and characterization of biopolymers from vegetable oils and glycerol following the principles of green chemistry |
| Grantee: | Gilbert Bannach |
| Support Opportunities: | Regular Research Grants |