Holanda, Bruno B. C.
Alarcon, Rafael T.
Guerra, Renan B.
Spazzini, Fabiola C. R.
Castro, Ricardo A. E.
Total Authors: 7
 UNESP Sao Paulo State Univ, Sch Sci, Chem Dept, BR-17033260 Bauru, SP - Brazil
 Coimbra Univ, Coll Pharm, P-3000578 Coimbra - Portugal
Total Affiliations: 2
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS;
Web of Science Citations:
In this work, the thermal decomposition of mebendazole (MBZ) was studied to elucidate divergent data found in the literature concerning the thermal behavior of this drug. To this end, thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), evolved gas analysis (EGA), and DSC-photovisual analysis were employed to fully evaluate the polymorphic form A of MBZ. Our results showed that mebendazole undergoes mass loss starting at 205 degrees C with the release of methanol and carbon monoxide. Characterization of the main thermal decomposition product of MBZ through mid-infrared spectroscopy (MIR), proton nuclear magnetic resonance (H-1 NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and powder X-ray diffraction (PXRD) indicated the formation of 2-amino-5-benzoylbenzimidazole (MBZ-A). Kinetic parameters for MBZ and MBZ-A were also evaluated and shown herein. (AU)