Overall survival and time trends in breast and cervical cancer incidence and mortality in the Regional Health District (RHD) of Barretos, SAo Paulo, Brazil

Author(s)

da Costa, Allini Mafra ^{[1, 2, 3]} ; Hashim, Dana ^[4] ; Tavares Guerreiro Fregnani, Jose Humberto ^[3] ; Weiderpass, Elisabete ^{[5, 4, 6, 7]}

Affiliation

^[1] Barretos Canc Hosp, Hosp Based Canc Registry, Rua Antenor Duarte Vilela 1331, BR-14784400 Barretos, SP - Brazil

^[2] Barretos Canc Hosp, Populat Based Canc Registry, BR-14784400 Barretos, SP - Brazil

^[3] Barretos Canc Hosp, Inst Educ & Res, BR-14784400 Barretos, SP - Brazil

^[4] Canc Registry Norway, Inst Populat Based Canc Res, Dept Res, Oslo - Norway

^[5] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm - Sweden

^[6] Arctic Univ Norway, Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso - Norway

^[7] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki - Finland

• Document type: Journal article
• Source: BMC CANCER; v. 18, NOV 7 2018.
• Web of Science Citations: 1

Abstract

BackgroundBreast and cervical cancers represent a significant cause of morbidity and mortality among women. The purpose of this study was to analyse the survival and time trends in two of the most common female cancers in the Regional Health District (RHD) of Barretos, SAo Paulo, Brazil.MethodsFrom 2000 through 2015, we calculated the breast and cervical cancer incidence and mortality rates per 100,000 women who were age-standardized to the world population. We obtained the time trends using the Joinpoint Regression software. We estimated the overall survival rates using the Kaplan-Meier methods.ResultsThe age-standardized rates (ASR) for incidence of breast cancer increased annually, with an average annual percentage change (AAPC) of 4.3 (95% Confidence Interval (CI): 2.4 to 6.3) for invasive breast cancer and 10.2 (95% CI: 6.1 to 14.5) for in situ breast cancer. The mortality rates for invasive breast cancer decreased with an AAPC of 0.2 (95% CI: -1.9 to 2.4). The ASR incidence of invasive cervical cancer showed an AAPC of -1.9 (95% CI: -4.7 to 0.9). For in situ cases, the ASR showed an AAPC of 9.3 (95% CI: 3.3 to 15.7). The ASR mortality for cervical cancer showed an AAPC of -5.3 (95% CI: -9.5 to -0.8). The Kaplan-Meier analysis indicated 5-year overall survival rates of 74.3% for breast cancer and 70.7% for cervical cancer.ConclusionsThe incidence of in situ and invasive breast cancer is increasing, while the mortality rates remain stable. We observed an increase in the incidence of in situ cervical cancer and a decrease in invasive incidence rates during the study period, and we noted that the cervical cancer mortality significantly declined during the study period. (AU)

• FAPESP's process: 17/03787-2 - Malignant neoplasms of the 18 cities of Barretos regional health district (RhD), São Paulo, Brazil: the importance of a Population-Based Cancer Registry
• Grantee: José Humberto Tavares Guerreiro Fregnani
• Support Opportunities: Research Projects - Thematic Grants