Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Design of Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas citri subsp citri

Full text
Author(s):
Show less -
Nazare, Ana Carolina [1] ; Polaquini, Carlos Roberto [1] ; Cavalca, Lucia Bonci [2, 3] ; Anselmo, Daiane Bertholin [1] ; Calmon Saiki, Marilia de Freitas [4] ; Monteiro, Diego Alves [4] ; Zielinska, Aleksandra [3] ; Rahal, Paula [4] ; Gomes, Eleni [4] ; Scheffers, Dirk-Jan [3] ; Ferreira, Henrique [2] ; Regasini, Luis Octavio [1]
Total Authors: 12
Affiliation:
[1] Sao Paulo State Univ, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] Sao Paulo State Univ, Biosci Inst, Dept Biochem & Microbiol, BR-13506900 Rio Claro, SP - Brazil
[3] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, NL-9747 AG Groningen - Netherlands
[4] Sao Paulo State Univ, Inst Biosci Humanities & Exact Sci, Dept Biol, IBILCE, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 19, n. 10 OCT 2018.
Web of Science Citations: 1
Abstract

Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study was to design antibacterial agents. In order to do this, we analyzed the anti-Xcc activity of 36 alkyl dihydroxybenzoates and we found 14 active compounds. Among them, three esters with the lowest minimum inhibitory concentration values were selected; compounds 4 (52 M), 16 (80 M) and 28 (88 M). Our study demonstrated that alkyl dihydroxybenzoates cause a delay in the exponential phase. The permeability capacity of alkyl dihydroxybenzoates in a quarter of MIC was compared to nisin (positive control). Compound 28 was the most effective (93.8), compared to compound 16 (41.3) and compound 4 (13.9) by percentage values. Finally, all three compounds showed inhibition of FtsZ GTPase activity, and promoted changes in protofilaments, leading to depolymerization, which prevents bacterial cell division. In conclusion, heptyl dihydroxybenzoates (compounds 4, 16 and 28) are promising anti-Xcc agents which may serve as an alternative for the control of citrus canker. (AU)

FAPESP's process: 13/50367-8 - New environmental-friendly compounds to combat citrus canker
Grantee:Henrique Ferreira
Support type: Regular Research Grants
FAPESP's process: 17/50216-0 - Using agricultural waste to combat plant pathogens environmental friendly ways to combat Xanthomonas citri
Grantee:Henrique Ferreira
Support type: Regular Research Grants
FAPESP's process: 15/50162-2 - Protecting plants with antimicrobial peptides and gallates - Pro-Planta
Grantee:Henrique Ferreira
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/18330-0 - Synthesis and biological evaluation of curcumin-cinnamaldehyde hybrids as bacterial cell division inhibitors
Grantee:Luis Octávio Regasini
Support type: Regular Research Grants