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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study

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Author(s):
Duarte, Poliana Mendes [1] ; Feres, Magda [1] ; Smeili Yassine, Lina Lameh [1] ; Silva Soares, Geisla Mary [2] ; Miranda, Tamires Szeremeske [1] ; Faveri, Marcelo [1] ; Retamal-Valdes, Belen [1] ; Figueiredo, Luciene Cristina [1]
Total Authors: 8
Affiliation:
[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Sao Paulo - Brazil
[2] Univ Fed Parana, Dept Stomatol, Curitiba, Parana - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 45, n. 11, p. 1326-1335, NOV 2018.
Web of Science Citations: 0
Abstract

Aim To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX). Material and Methods Results Diabetic and nondiabetic subjects with severe periodontitis received SRP + MTZ (400 mg/thrice a day {[}TID]) + AMX (500 mg/TID) for 14 days. Subgingival biofilm samples were analyzed by checkerboard DNA-DNA hybridization for 40 bacterial species. Subjects were monitored at baseline, 3, 6 and 12 months post-therapy. Twenty-nine type 2 diabetics and 29 non-diabetic subjects participated of this study. Of the non-diabetics and diabetics, 68.9% and 75.9%, respectively, reached the clinical endpoint for treatment (<= 4 sites with probing depth {[}PD] >= 5 mm) at 1 year post-therapy (p > 0.05). The diabetic group presented lower mean clinical attachment gain from baseline to 1 year post-therapy and higher mean proportions of the red and orange complexes than the non-diabetic group (p < 0.05). Conclusions Non-diabetic subjects with severe periodontitis did not respond better than type 2 diabetic subjects to the treatment protocol of SRP + MTZ + AMX, both in terms of achieving the clinical endpoint for treatment and of PD improvement. Diabetic subjects exhibited a slightly worse microbiological response and showed a healing process more associated with gingival recession than the non-diabetics. (AU)

FAPESP's process: 11/14872-4 - Systemic metronidazole and amoxicillin as adjuncts to scaling and root planing in the treatment of chronic periodontitis in type 2 diabetic subjects: clinical, glycemic and microbiological evaluations
Grantee:Tamires Szeremeske de Miranda
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/01072-5 - Systemic metronidazole and amoxicillin as adjuncts to scaling and root planing in the treatment of chronic periodontitis in type 2 diabetic subjects: clinical, glycemic and microbiological evaluations
Grantee:Poliana Mendes Duarte
Support type: Regular Research Grants