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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior

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Author(s):
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Motta-Teixeira, Livia Clemente [1] ; Machado-Nils, Aline Vilar [2] ; Battagello, Daniella Sabino [3] ; Diniz, Giovanne Baroni [3] ; Andrade-Silva, Jessica [1] ; Silva Jr, Sinesio ; Matos, Raphael Afonso [4] ; do Amaral, Fernanda Gaspar [5, 4] ; Xavier, Gilberto Fernando [2] ; Bittencourt, Jackson Cioni [3] ; Reiter, Russel J. [6] ; Lucassen, Paul John [7] ; Korosi, Aniko [7] ; Cipolla-Neto, Jose [4]
Total Authors: 14
Affiliation:
[1] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Av Lineu Prestes 1524, Bldg 1, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Biosci Inst, Dept Physiol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, SP - Brazil
[4] Silva Jr, Jr., Sinesio, Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Av Lineu Prestes 1524, Bldg 1, BR-05508000 Sao Paulo, SP - Brazil
[5] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, SP - Brazil
[6] Univ Texas San Antonio, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78284 - USA
[7] Univ Amsterdam, Swammerdam Inst Life Sci, Brain Plast Grp, Amsterdam - Netherlands
Total Affiliations: 7
Document type: Journal article
Source: Hormones and Behavior; v. 105, p. 146-156, SEP 2018.
Web of Science Citations: 1
Abstract

Maternal melatonin provides photoperiodic information to the fetus and thus influences the regulation and timing of the offspring's internal rhythms and preparation for extra-uterine development. There is clinical evidence that melatonin deprivation of both mother and fetus during pregnancy, and of the neonate during lactation, results in negative long-term health outcomes. As a consequence, we hypothesized that the absence of maternal pineal melatonin might determine abnormal brain programming in the offspring, which would lead to long-lasting implications for behavior and brain function. To test our hypothesis, we investigated in rats the effects of maternal melatonin deprivation during gestation and lactation (MMD) to the offspring and the effects of its therapeutic replacement. The parameters evaluated were: (1) somatic, physical growth and neurobehavioral development of pups of both sexes; (2) hippocampal-dependent spatial learning and memory of the male offspring; (3) adult hippocampal neurogenesis of the male offspring. Our findings show that MMD significantly delayed male offspring's onset of fur development, pinna detachment, eyes opening, eruption of superior incisor teeth, testis descent and the time of maturation of palmar grasp, righting reflex, free-fall righting and walking. Conversely, female offspring neurodevelopment was not affected. Later on, male offspring show that MMD was able to disrupt both spatial reference and working memory in the Morris Water Maze paradigm and these deficits correlate with changes in the number of proliferative cells in the hippocampus. Importantly, all the observed impairments were reversed by maternal melatonin replacement therapy. In summary, we demonstrate that MMD delays the appearance of physical features, neurodevelopment and cognition in the male offspring, and points to putative public health implications for night shift working mothers. (AU)

FAPESP's process: 16/02748-0 - Study of the anatomical basis for a volume transmission mechanism on the Melanin Concentrating Hormone [MCH] peptidergic system
Grantee:Giovanne Baroni Diniz
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 10/52068-0 - The putative envolvement of melanin-concentrating hormone in the control of lactation
Grantee:Jackson Cioni Bittencourt
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/50457-0 - Melatonin and the control of energy metabolism: basic, clinical and epidemiological research
Grantee:José Cipolla Neto
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/04554-8 - Identification, molecular characterization, mapping and colocalization of the receptor 1 melanin-concentrating hormone in mammary gland of lactating and non-lactating rats
Grantee:Daniella Sabino Battagello
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/18941-4 - Effects of maternal melatonin deprivation during pregnancy and lactation on the offspring neuroimmune system
Grantee:Lívia Clemente Motta Teixeira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 16/02224-1 - The existence of neurogenesis during the lactation period
Grantee:Jackson Cioni Bittencourt
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/22313-3 - Influence of the absence of maternal melatonin during pregnancy and lactation on neurogenesis and on somatic and sensorimotor development of the offspring
Grantee:Lívia Clemente Motta Teixeira
Support type: Scholarships in Brazil - Doctorate