Biological activity of 7 beta-acetoxywithanolide D isolated from Acnistus arborescens

Author(s)

Marciano Correa, Joze Aparecida ^[1] ; Fortkamp, Diana ^[1] ; da Silva, Camila Furtunato ^[2] ; Rocha, Flavio ^[1] ; Gomes, Luiz Humberto ^[3] ; Roncato Duarte, Keila Maria ^[4] ; Ferreira, Antonio Gilberto ^[3] ; de Lira, Simone Possedente ^[5]

Affiliation

^[1] Univ Sao Paulo, Programa Posgrad Microbiol Agr, Escola Super Agr Luiz de Queiroz, Dept Ciencias Exatas, Piracicaba, SP - Brazil

^[2] Univ Sao Paulo, ESALQ, Dept Ciencias Exatas, Curso Grad Ciencias Alimentos, Piracicaba, SP - Brazil

^[3] Univ Sao Paulo, ESALQ, Dept Ciencias Exatas, Piracicaba, SP - Brazil

^[4] APTA Reg Polo Ctr Sul, Unidade Pesquisa Tiete, Tiete, SP - Brazil

^[5] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: SEMINA-CIENCIAS AGRARIAS; v. 39, n. 6, p. 2835-2841, NOV-DEC 2018.
• Web of Science Citations: 0

Abstract

Many oomycete species are plant pathogens and are responsible for causing significant losses in agriculture. Currently, plant pathogen control is carried out by chemical, biological and physical methods. However, due to the development of resistance to these methods by some pathogens, it is imperative that alternative methods are developed. Brazilian biodiversity is well-known for its species richness and is considered a promising source of natural products. Among the vascular plants, the family Solanaceae A. Juss. (Solanaceac) is considered one of the largest, with distributions across all tropical and temperate regions of the world. The Solanaceae family presents a high diversity of species of economic importance as sources of food, medicinal and ornamental properties. Plants of this family are sources of secondary metabolites of various chemical classes that possess potential diverse applications. Therefore, chemical and biological investigations of these compounds are extremely important as they present alternatives for their potential use in the control of plant pathogens. Here, we report for the first time, the biological activity of 7 beta-acetoxywithanolide D, a compound isolated from Acnistus arborescens, against the oomycete Phytophthora cinnamomi. With these results, we emphasize the importance of such studies on plant secondary metabolites, which may present coadjuvant options in the control of plant pathogens. (AU)

• FAPESP's process: 12/02861-0 - Bioprospection of solanaceous (Solanaceae) with fungitoxic activity against Moniliophthora perniciosa
• Grantee: Flávio Rocha
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
• Grantee: Roberto Gomes de Souza Berlinck
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 14/15760-3 - Biotechnological potential of secondary metabolites from plants and endophytic fungi
• Grantee: Simone Possedente de Lira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/09349-0 - Chemical and Biological studies of two Solanum species extracts presenting Moniliophthora perniciosa anti-fungi activity (cocoa witches´broom disease)
• Grantee: Camila Furtunato da Silva
• Support Opportunities: Scholarships in Brazil - Scientific Initiation