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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Endemicity of the High-Risk Clone Klebsiella pneumoniae ST340 Coproducing QnrB, CTX-M-15, and KPC-2 in a Brazilian Hospital

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Tolentino, Fernanda Modesto [1, 2, 3] ; Campagnari Bueno, Maria Fernanda [4] ; Franscisco, Gabriela Rodrigues [4] ; de Paula Barcelos, Diego Diniz [2] ; Lobo, Suzana Margareth [2] ; Moreira Batista Tomaz, Francieli Maira [2] ; da Silva, Natal Santos [5, 2] ; de Andrade, Leonardo Neves [6] ; Casella, Tiago [2, 7] ; da Costa Darini, Ana Lucia [6] ; Polotto, Milena [1, 2] ; Garcia, Doroti de Oliveira [4] ; Lelles Nogueira, Mara Correa [2]
Total Authors: 13
[1] Adolfo Lutz Inst, Sao Jose Do Rio Preto - Brazil
[2] Fac Med Sao Jose Do Rio Preto, Dept Doencas Dermatol Infecciosas & Parasitarias, Ctr Invest Microrganismos, Sao Jose Do Rio Preto - Brazil
[3] Univ Estadual Paulista, Sao Jose Do Rio Preto - Brazil
[4] Adolfo Lutz Inst, Ctr Bacteriol, Sao Paulo - Brazil
[5] Uniao Fac Grandes Lagos, Lab Modelagens Matemat & Estat Med, Sao Jose Do Rio Preto, SP - Brazil
[6] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto - Brazil
[7] Hosp Base, Lab Cent, Setor Microbiol Clin, Sao Jose Do Rio Preto - Brazil
Total Affiliations: 7
Document type: Journal article
Source: MICROBIAL DRUG RESISTANCE; v. 25, n. 4 DEC 2018.
Web of Science Citations: 1

The dissemination of multiresistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing Klebsiella pneumoniae isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant K. pneumoniae isolated from 2011 to 2014 in a tertiary hospital were investigated. The bla(KPC-2) gene was the only determinant for carbapenem resistance. The bla(CTX-M-15) gene was the main determinant for the production of extended-spectrum beta-lactamase (ESBL), whereas aph(3 `)-Ia and qnrB were the most common genes associated with resistance to aminoglycosides and quinolones, respectively. Nine different sequence types (STs) were identified. The most common was ST340. Molecular typing by enterobacterial repetitive intergenic consensus-PCR placed 48 strains among 10 different clusters. In the studied hospital, the high-risk clone of KPC-2-producing K. pneumoniae ST340, harboring genes that codify aminoglycoside modifying enzymes, QnrB and CTX-M-15 plus CTXM-2-type ESBLs, is disseminated and acts as a major agent of infections in critically ill patients. (AU)

FAPESP's process: 12/21709-5 - Genetic diversity of KPC-producing Klebsiella pneumoniae isolated from several hospitals of São Paulo State
Grantee:Doroti de Oliveira Garcia
Support type: Regular Research Grants
FAPESP's process: 14/17184-0 - Identification of genes codifying ESBLs, quinolone resistance and virulence in E. coli isoltaed from chickens, chicken meat and patients with urinary tract infections
Grantee:Mara Corrêa Lelles Nogueira
Support type: Regular Research Grants