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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Physicochemical characterization of albumin immobilized on different TiO2 surfaces for use in implant materials

Full text
Author(s):
Bronze-Uhle, Erika S. [1] ; Dias, Leonardo F. G. [1] ; Trino, Luciana D. [1] ; Matos, Adriana A. [2] ; de Oliveira, Rodrigo C. [2] ; Lisboa-Filho, Paulo N. [1]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ, UNESP, Sch Sci, Dept Phys, Bauru, SP - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 564, p. 39-50, MAR 5 2019.
Web of Science Citations: 0
Abstract

Osseointegration process may be defined as the structural and functional connection between living bone and the surface of an implant, promoting adequate cell adhesion, proliferation, and differentiation. One strategy to increase the biocompatibility and consequently generate greater osteogenesis is to modify the surfaces of implants to alter the process of the bone tissue repair. Surface modifications in titanium implants were proposed using organic bifunctional spacers (3-mercaptopropionic acid, MPA, and 3-aminopropyltrimethoxysilane, APTMS) or direct albumin (BSA) immobilization. Chemical immobilization of BSA, either physically or covalently, on TiO2 substrates showed similar surface chemistry without altering long-term cellular interaction. Furthermore, TiO2-APTMS substrate with -NH2 groups on the surface more efficiently interacts with components of the extracellular matrix, presenting high cell viability at 48 h and better viability and mineralization results. (AU)

FAPESP's process: 14/01713-3 - Functionalization and adsorption studies on thin oxide films
Grantee:Luciana Daniele Trino Albano
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/20471-0 - Functionalized metal oxides thin films for the study of protein adsorption
Grantee:Paulo Noronha Lisboa Filho
Support Opportunities: Regular Research Grants
FAPESP's process: 16/11183-7 - Deposition and functionalization of TiO2 thin films surface
Grantee:Leonardo Francisco Gonçalves Dias
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/15035-5 - Adsorption of bisphosphonates and proteins on TiO2 surfaces for bone implants
Grantee:Paulo Noronha Lisboa Filho
Support Opportunities: Regular Research Grants