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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Recent Advances in the Use of Galleria mellonella Model to Study Immune Responses against Human Pathogens

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Pereira, Thais Cristine [1] ; de Barros, Patricia Pimentel [1] ; de Oliveira Fugisaki, Luciana Ruano [1] ; Rossoni, Rodnei Dennis [1] ; Ribeiro, Felipe de Camargo [1] ; de Menezes, Raquel Teles [1] ; Junqueira, Juliana Campos [1] ; Scorzoni, Liliana [1]
Total Authors: 8
[1] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: JOURNAL OF FUNGI; v. 4, n. 4 DEC 2018.
Web of Science Citations: 15

The use of invertebrates for in vivo studies in microbiology is well established in the scientific community. Larvae of Galleria mellonella are a widely used model for studying pathogenesis, the efficacy of new antimicrobial compounds, and immune responses. The immune system of G. mellonella larvae is structurally and functionally similar to the innate immune response of mammals, which makes this model suitable for such studies. In this review, cellular responses (hemocytes activity: phagocytosis, nodulation, and encapsulation) and humoral responses (reactions or soluble molecules released in the hemolymph as antimicrobial peptides, melanization, clotting, free radical production, and primary immunization) are discussed, highlighting the use of G. mellonella as a model of immune response to different human pathogenic microorganisms. (AU)

FAPESP's process: 17/02652-6 - Evaluation of the immunomodulatory and antifungal effects of caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin C (ARC) on C. albicans and development of candidiasis in in vivo model hosts
Grantee:Patricia Pimentel de Barros
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/19219-3 - Identification of bioactive substances produced by Lactobacillus paracasei 28.4 for the control of oral candidiasis
Grantee:Rodnei Dennis Rossoni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/25544-1 - Development of probiotic formulations for bucal candidiasis prevention: in vitro and in vivo study
Grantee:Felipe de Camargo Ribeiro
Support type: Scholarships in Brazil - Doctorate