Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Applications of Invertebrate Animal Models to Dimorphic Fungal Infections

Full text
Singulani, Junya L. [1] ; Scorzoni, Liliana [2, 1] ; de Oliveira, Haroldo C. [1] ; Marcos, Caroline M. [1] ; Assato, Patricia A. [1] ; Fusco-Almeida, Ana Marisa [1] ; Mendes-Giannini, Maria Jose S. [1]
Total Authors: 7
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Sci & Technol, BR-12245000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF FUNGI; v. 4, n. 4 DEC 2018.
Web of Science Citations: 5

Dimorphic fungi can be found in the yeast form during infection and as hyphae in the environment and are responsible for a large number of infections worldwide. Invertebrate animals have been shown to be convenient models in the study of fungal infections. These models have the advantages of being low cost, have no ethical issues, and an ease of experimentation, time-efficiency, and the possibility of using a large number of animals per experiment compared to mammalian models. Invertebrate animal models such as Galleria mellonella, Caenorhabditis elegans, and Acanthamoeba castellanii have been used to study dimorphic fungal infections in the context of virulence, innate immune response, and the efficacy and toxicity of antifungal agents. In this review, we first summarize the features of these models. In this aspect, the growth temperature, genome sequence, availability of different strains, and body characteristics should be considered in the model choice. Finally, we discuss the contribution and advances of these models, with respect to dimorphic fungi Paracoccidioides spp., Histoplasma capsulatum, Blastomyces dermatitidis, Sporothrix spp., and Talaromyces marneffei (Penicillium marneffei). (AU)

FAPESP's process: 16/17048-4 - Two-component signal transduction (TCST) system as a new target for the treatment of paracoccidioidomycosis
Grantee:Caroline Maria Marcos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/06658-9 - Platform for antifungal development in a nanostructured lipid system aiming at efficacy and safety in alternative animal models
Grantee:Junya de Lacorte Singulani
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/14023-8 - Use of peptides with anti-adhesive activity in Paracoccidoides spp. in the treatment and prophylaxis of the paracoccidioidomycosis
Grantee:Haroldo Cesar de Oliveira
Support type: Scholarships in Brazil - Post-Doctorate