Relevance of serum angiogenic cytokines in adult patients with dermatomyositis

Author(s)

Pamplona da Silva, Thiago Costa ^[1] ; Silva, Marilda Guimaraes ^[1] ; Shinjo, Samuel Katsuyuki ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Av Dr Arnaldo 455, 3 Andar, Sala 3150, BR-01246903 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: ADVANCES IN RHEUMATOLOGY; v. 58, JUL 31 2018.
• Web of Science Citations: 1

Abstract

Abstract Background: Until now, there are few studies evaluating serum levels of angiogenic cytokines in dermatomyositis (DM). Therefore, the aims of the present study were: (a) to analyze systematically and simultaneously serum levels of angiogenin (ANG), angiopoietin (ANGPT)-1, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)- 1 and - 2, platelet derived growth factor (PDGF)-AA and -BB in DM; (b) to correlate the serum level of these cytokines with the DM clinical and laboratory features. Methods: This is a cross sectional study, in which 48 patients with DM aged 18 to 45 years were gender-, age- and ethnicity-matched with 48 healthy individuals (control group). The serum levels of cytokines analyses were performed by multiplex immunoassay. The parameters of DM activity were based on the scores established by the International Myositis Assessment & Clinical Studies Group. Results: The mean ages, gender frequencies and ethnicities were comparable between the patients with DM and the control group. A significantly higher serum FGF-1 and FGF-2 levels (P < 0.001 and P < 0.001, respectively), lower VEGF and PDGF-AA levels (P = 0.009 and P = 0.022), and comparable ANG, ANGPT-1 and PDGF-BB levels were observed in DM patients compared to controls. There was a tendency for cytokines (with the exceptions of VEGF and PDGF-BB) to correlate positively with the DM activity parameters, whereas FGF-2 correlated inversely. Moreover, FGF-1 strongly correlated with DM cutaneous manifestations. Conclusions: The present data provide the relevance of different serum angiogenic cytokines in patients with DM. Additional studies will be needed to validate the data obtained in this work. (AU)

• FAPESP's process: 12/09633-3 - Gene expression of proinflammatory cytokines in muscle biopsies of patients with dermatomyositis/polymyositis: correlation with clinical and laboratory features and outcome
• Grantee: Samuel Katsuyuki Shinjo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/07101-4 - Serum cytokines and its gene expression: correlation with clinical and laboratory features and metabolic alterations of dermatomyositis/polymyositis
• Grantee: Samuel Katsuyuki Shinjo
• Support Opportunities: Regular Research Grants