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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by Salmonella/Microsome Test

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Damasceno, Jaqueline Lopes [1] ; Arnet, Yadira Fernandez [1] ; Fortunato, Giovanna Capaldi [2] ; Girotto, Luiza [2] ; Marena, Gabriel Davi [2] ; Rocha, Beatriz Patti [2] ; Resende, Flavia Aparecida [2] ; Ambrosio, Sergio Ricardo [1] ; Sola Veneziani, Rodrigo Cassio [1] ; Bastos, Jairo Kenupp [3] ; Gomes Martins, Carlos Henrique [1]
Total Authors: 11
[1] Univ Franca, Lab Res Appl Microbiol LAPEMA, Ave Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP - Brazil
[2] Univ Araraquara, Dept Biol Sci & Hlth, Rua Carlos Gomes 1338, BR-14801320 Araraquara, SP - Brazil
[3] Univ Sao Paulo, Dept Pharmaceut Sci, Sch Pharmaceut Sci, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Evidence-based Complementary and Alternative Medicine; 2019.
Web of Science Citations: 1

Trees of the Copaifera genus are native to the tropical regions of Latin America and Western Africa. Copaifera sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in Copaifera and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Bearing in mind the fact that the Ames test is an excellent tool to assess the safety of extracts, oils, and phytochemicals isolated from medicinal plants, from it, we evaluate the mutagenic potential of four species, between oleoresins (C. oblongifolia; C. langsdorffii) and leaves extracts (C. lucens; C. multijuga), of the Copaifera genus and also of kaurenoic acid, which is one of its major compounds. The results showed that the Copaifera spp. and kaurenoic acid did not induce an increase in the number of revertant colonies, without mutagenic effect in experiments, in the all concentrations evaluated by Ames test. The results obtained in our study support the safe use of the Copaifera genus medicinal plants selected and of kaurenoic acid. (AU)

FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
Grantee:Jairo Kenupp Bastos
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/25237-0 - Kaurane-type diterpenes: activity against anaerobic bacteria and proteomics
Grantee:Carlos Henrique Gomes Martins
Support type: Regular Research Grants