Cardiorespiratory Fitness and Risk of All-Cause, Cardiovascular Disease, and Cancer Mortality in Men With Musculoskeletal Conditions

Author(s)

Lemes, Italo Ribeiro ^[1] ; Sui, Xuemei ^[2] ; Fritz, Stacy L. ^[2] ; Beattie, Paul F. ^[2] ; Lavie, Carl J. ^[3] ; Turi-Lynch, Bruna Camilo ^[4] ; Blair, Steven N. ^[2]

Affiliation

^[1] Sao Paulo State Univ UNESP, Fac Sci & Technol, Dept Phys Therapy, Presidente Prudente - Brazil

^[2] Univ South Carolina, Dept Exercise Sci, Arnold Sch Publ Hlth, Columbia, SC 29208 - USA

^[3] Univ Queensland, Sch Med, John Ochsner Heart & Vasc Inst, Dept Cardiovasc Dis, Ochsner Clin Sch, New Orleans, LA - USA

^[4] Sao Paulo State Univ UNESP, Inst Biosci, Dept Phys Educ, Rio Claro - Brazil

• Document type: Journal article
• Source: JOURNAL OF PHYSICAL ACTIVITY & HEALTH; v. 16, n. 2, p. 134-140, FEB 2019.
• Web of Science Citations: 0

Abstract

Background: To investigate the association between cardiorespiratory fitness and risk of cardiovascular disease, cancer, and all-cause mortality in men with musculoskeletal conditions. Methods: Participants were 12,728 men (mean age 47.0 {[}9.3] y) with a history of musculoskeletal conditions (including joint pain, low back pain, stiff joints, arthritis, osteoporosis, or gout) and were followed for all-cause mortality to December 31, 2003. Fitness was quantified by maximal treadmill exercise test and was categorized for analysis as low, moderate, and high performance. Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals. Results: Overall, the multivariable-adjusted hazard ratios and 95% confidence intervals for mortality across incremental fitness categories were 1.00 (reference), 0.45 (0.30-0.68) and 0.35 (0.22-0.53), linear trend P < .01 for all-cause, 0.50 (0.23-1.10) and 0.29 (0.12-0.71), linear trend P = .02 for cardiovascular disease, and 0.38 (0.20-0.74) and 0.40 (0.20-0.80), linear trend P = .01 for cancer mortality. Conclusion: Among men with musculoskeletal conditions, higher fitness is associated with lower risk of death by cardiovascular disease, cancer, or any cause, independent of other risk factors. (AU)

• FAPESP's process: 16/11140-6 - Physical activity, obesity and risk factors for metabolic syndrome in the brazilian public health system: a longitudinal study
• Grantee: Ítalo Ribeiro Lemes
• Support type: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 15/17777-3 - Physical activity, risk factors for metabolic syndrome and healthcare expenditures among users of the Brazilian national health system: 8-year longitudinal study
• Grantee: Ítalo Ribeiro Lemes
• Support type: Scholarships in Brazil - Doctorate