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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fetal-Derived MyD88 Signaling Contributes to Poor Pregnancy Outcomes During Gestational Malaria

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Author(s):
Barboza, Renato [1] ; Hasenkamp, Lutero [2] ; Barateiro, Andre [2] ; Murillo, Oscar [2] ; Machado Peixoto, Erika Paula [2] ; Lima, Flavia Afonso [2] ; Reis, Aramys Silva [2] ; Goncalves, Ligia Antunes [2] ; Epiphanio, Sabrina [3] ; Marinho, Claudio R. F. [2]
Total Authors: 10
Affiliation:
[1] Univ Fed Sao Paulo, Dept Ciencias Biol, Diadema - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN MICROBIOLOGY; v. 10, JAN 29 2019.
Web of Science Citations: 1
Abstract

Placental malaria (PM) remains a severe public health problem In areas of high malaria transmission. Despite the efforts to prevent Infection poor outcomes in Plasmodium endemic areas, there is still a considerable number of preterm births and newborns with low birth weight resulting from PM. Although local Inflammation triggered In response to malaria is considered crucial In Inducing placental damage, little Is known about the differential Influence of maternal and fetal Immune responses to the disease progression. Therefore, using a PM mouse model, we sought to determine the contribution of maternal and fetal innate immune responses to PM development. For this, we conducted a series of cross-breeding experiments between mice that had differential expression of the MyD88 adaptor protein to obtain mother and correspondent fetuses with distinct genetic backgrounds. By evaluating fetal weight and placental vascular spaces, we have shown that the expression of MyD88 In fetal tissue has a significant impact on PM outcomes. Our results highlighted the existence of a distinct contribution of maternal and fetal immune responses to PM onset. Thus, contributing to the understanding of how inflammatory processes lead to the dysregulatlon of placental homeostasis ultimately impairing fetal development. (AU)

FAPESP's process: 09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria
Grantee:Cláudio Romero Farias Marinho
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 09/53256-7 - Distress syndrome in a murine model associated to the severe malaria: a study of parasite-host interaction
Grantee:Sabrina Epiphanio
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/14715-9 - Role of the adaptor protein MyD88 on the placental malaria
Grantee:Lutero Augusto Hasenkamp
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/10892-1 - Study of the inflammatory mechanisms mediated by innate immunity receptors in Amyotrophic Lateral Sclerosis
Grantee:Renato Barboza
Support type: Regular Research Grants
FAPESP's process: 11/19048-8 - Role of inflamassoma in the immunopathogenesis of placental malaria
Grantee:Aramys Silva dos Reis
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/16417-8 - Autophagy in placental malaria: effects and mechanisms
Grantee:Flávia Afonso Lima
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/07030-0 - Characterization of autophagic activity and inflammasome in placental malaria
Grantee:Cláudio Romero Farias Marinho
Support type: Regular Research Grants
FAPESP's process: 17/03939-7 - Impact of autophagy and inflammasome on the pathogenesis of Placental Malaria
Grantee:André Filipe Rivais Martins Barateiro
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/17880-8 - Toll-like receptors and NOD-like receptors in pregnancy-associated malaria pathogenesis: effects and mechanisms
Grantee:Renato Barboza
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/06106-0 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms
Grantee:Cláudio Romero Farias Marinho
Support type: Research Grants - Visiting Researcher Grant - International