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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review

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Mariana Zorrón Mei Hsia Pu ; Flávia Corrêa Christensen-Adad ; Aline Cristina Gonçalves ; Walter José Minicucci ; José Dirceu Ribeiro ; Antonio Fernando Ribeiro
Total Authors: 6
Document type: Journal article
Source: Revista Paulista de Pediatria; v. 34, n. 3, p. -, Set. 2016.

Abstract Objective: To elucidate whether insulin is effective or not in patients with cystic fibrosis before the diabetes mellitus phase. Data source: The study was performed according to the Prisma method between August and September 2014, using the PubMed, Embase, Lilacs and SciELO databases. Prospective studies published in English, Portuguese and Spanish from 2002 to 2014, evaluating the effect of insulin on weight parameters, body mass index and pulmonary function in patients with cystic fibrosis, with a mean age of 17.37 years before the diabetes mellitus phase were included. Data synthesis: Eight articles were identified that included 180 patients undergoing insulin use. Sample size ranged from 4 to 54 patients, with a mean age ranging from 12.4 to 28 years. The type of follow-up, time of insulin use, the dose and implementation schedule were very heterogeneous between studies. Conclusions: There are theoretical reasons to believe that insulin has a beneficial effect in the studied population. The different methods and populations assessed in the studies do not allow us to state whether early insulin therapy should or should not be carried out in patients with cystic fibrosis prior to the diagnosis of diabetes. Therefore, studies with larger samples and insulin use standardization are required. (AU)

FAPESP's process: 14/00611-2 - Saliva as method diagnostic of the cystic fibrosis
Grantee:Aline Cristina Gonçalves
Support type: Scholarships in Brazil - Doctorate