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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prior intake of Brazil nuts attenuates renal injury induced by ischemia and reperfusion

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Author(s):
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Natassia Alberici Anselmo [1] ; Leticia Colombo Paskakulis [2] ; Renata Correia Garcias [3] ; Fernanda Fortuci Resende Botelho [4] ; Giovana Queda Toledo [5] ; Maria Fernanda Ribeiro Cury [6] ; Natiele Zanardo Carvalho [7] ; Glória Elisa Florido Mendes [8] ; Tatiane Iembo [9] ; Thaís Santana Gastardelo Bizotto [10] ; Patricia Maluf Cury [11] ; Agnaldo Bruno Chies [12] ; Carla Patrícia Carlos [13]
Total Authors: 13
Affiliation:
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[1] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[2] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[3] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[4] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[5] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[6] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[7] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[8] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[9] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[10] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[11] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
[12] Faculdade de Medicina de Marília. Laboratório de Farmacologia - Brasil
[13] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa Experimental - Brasil
Total Affiliations: 13
Document type: Journal article
Source: J. Bras. Nefrol.; v. 40, n. 1, p. 10-17, 2018-04-19.
Abstract

ABSTRACT Introduction: Ischemia-reperfusion (IR) injury results from inflammation and oxidative stress, among other factors. Because of its anti-inflammatory and antioxidant properties, the Brazil nut (BN) might attenuate IR renal injury. Objective: The aim of the present study was to investigate whether the intake of BN prevents or reduces IR kidney injury and inflammation, improving renal function and decreasing oxidative stress. Methods: Male Wistar rats were distributed into six groups (N=6/group): SHAM (control), SHAM treated with 75 or 150 mg of BN, IR, and IR treated with 75 or 150 mg of BN. The IR procedure consisted of right nephrectomy and occlusion of the left renal artery with a non-traumatic vascular clamp for 30 min. BN was given daily and individually for 7 days before surgery (SHAM or IR) and maintained until animal sacrifice (48h after surgery). We evaluated the following parameters: plasma creatinine, urea, and phosphorus; proteinuria, urinary output, and creatinine clearance; plasmatic TBARS and TEAC; kidney expression of iNOS and nitrotyrosine, and macrophage influx. Results: Pre-treatment with 75 mg of BN attenuated IR-induced renal changes, with elevation of creatinine clearance and urinary output, reducing proteinuria, urea, and plasmatic phosphorus as well as reducing kidney expression of iNOS, nitrotyrosine, and macrophage influx. Conclusion: Low intake of BN prior to IR-induced kidney injury improves renal function by inhibition of macrophage infiltration and oxidative stress. (AU)

FAPESP's process: 15/18313-0 - Experimental study of the Effect of Brazil nuts in renal injury induced by ischemia and reperfusion
Grantee:Letícia Colombo Paskakulis
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/25616-0 - Oxidative stress and renal inflammation in rats submitted to ischemia-reperfusion and antioxidant treatment
Grantee:Renata Correia Garcias
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/08232-3 - Histopathological study of renal injury induced by ischemia and reperfusion in rats subjected to the ingestion of Brazil nuts
Grantee:Natássia Alberici Anselmo
Support Opportunities: Scholarships in Brazil - Scientific Initiation