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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods

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Artur M.N. Coutinho ; Fábio H.G. Porto ; Poliana F. Zampieri ; Maria C. Otaduy ; Tíbor R. Perroco ; Maira O. Oliveira ; Rafael F. Nunes ; Toulouse Leusin Pinheiro ; Cassio M.C. Bottino ; Claudia C. Leite ; Carlos A. Buchpiguel
Total Authors: 11
Document type: Journal article
Source: Dement. Neuropsychol.; v. 9, n. 4, p. -, Dez. 2015.
Abstract

ABSTRACT Reduction of regional brain glucose metabolism (rBGM) measured by [18F]FDG-PET in the posterior cingulate cortex (PCC) has been associated with a higher conversion rate from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Magnetic Resonance Spectroscopy (MRS) is a potential biomarker that has disclosed Naa/mI reductions within the PCC in both MCI and AD. Studies investigating the relationships between the two modalities are scarce. OBJECTIVE To evaluate differences and possible correlations between the findings of rBGM and NAA/mI in the PCC of individuals with AD, MCI and of cognitively normal volunteers. METHODS Patients diagnosed with AD (N=32) or MCI (N=27) and cognitively normal older adults (CG, N=28), were submitted to [18F]FDG-PET and MRS to analyze the PCC. The two methods were compared and possible correlations between the modalities were investigated. RESULTS The AD group exhibited rBGM reduction in the PCC when compared to the CG but not in the MCI group. MRS revealed lower NAA/mI values in the AD group compared to the CG but not in the MCI group. A positive correlation between rBGM and NAA/mI in the PCC was found. NAA/mI reduction in the PCC differentiated AD patients from control subjects with an area under the ROC curve of 0.70, while [18F]FDG-PET yielded a value of 0.93. CONCLUSION rBGM and Naa/mI in the PCC were positively correlated in patients with MCI and AD. [18F]FDG-PET had greater accuracy than MRS for discriminating AD patients from controls. (AU)

FAPESP's process: 11/18245-4 - Predictor factors of the cognitive outcome in subjects with mild cognitive impairment submitted to aerobic physical exercise
Grantee:Sonia Maria Dozzi Brucki
Support type: Regular Research Grants
FAPESP's process: 09/17398-1 - Correlation analysis of changes in structural volume, perfusion and glucose metabolism in Alzheimer's disease, mild cognitive impairment and normal aging
Grantee:Carlos Alberto Buchpiguel
Support type: Regular Research Grants