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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sjogren's syndrome and systemic lupus erythematosus: links and risks

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Pasoto, Sandra Gofinet [1, 2] ; de Oliveira Martins, Victor Adriano [1] ; Bonfa, Eloisa [1]
Total Authors: 3
[1] Univ Sao Paulo, Fac Med, Rheumatol Div, Hosp Clin, Ave Dr Arnaldo, 455, 3 Andar, Sala 3190, BR-01246903 Sao Paulo, SP - Brazil
[2] Univ Paulo HCFMUSP, Fac Med, Lab Div, Hosp Clin, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Review article
Web of Science Citations: 4

Systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. The prominent feature of SS is the impairment of the lacrimal and salivary glands leading to sicca symptoms. This disease may be classified as primary Sjogren's syndrome (pSS), or secondary Sjogren's syndrome (sSS) since it is often associated to other autoimmune disorders, principally SLE, rheumatoid arthritis, and systemic sclerosis. Systematic reviews and meta-analyses show an sSS prevalence in SLE patients of about 14%-17.8%. Herein, we updated important aspects of the clinical association between SLE and sSS through a narrative review of the PubMed database in the last 5 years (from July 2013 to October 2018) with the terms ``Sjogren syndrome and systemic lupus erythematosus{''}. The following aspects are addressed: the classification criteria for sSS; differences and similarities between SLE and pSS regarding demographic, clinical, and serological characteristics (including new autoantibodies), as well as comorbidities; the etiopathogenic links between SLE and pSS (including genetic and environmental factors, B-cell activation, and autoantibodies); the predictive factors for sSS onset in SLE patients; the ocular and oral involvements due to sSS in SLE; and the main distinctive demographic, clinical, and serological features of SLE with and without associated SS. (AU)

FAPESP's process: 15/03756-4 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy
Grantee:Eloisa Silva Dutra de Oliveira Bonfá
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/09937-9 - Analysis of the immune profile of saliva and serum of patients with primary Sjogren's Syndrome
Grantee:Victor Adriano de Oliveira Martins
Support type: Scholarships in Brazil - Doctorate (Direct)