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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis

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Lee, Dong Hoon [1] ; Machado de Rezende, Leandro Fornias [2] ; Hu, Frank B. [3, 4, 1, 5] ; Jeon, Justin Y. [6, 7] ; Giovannucci, Edward L. [3, 4, 1, 5]
Total Authors: 5
[1] Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Bldg 2, 3rd Floor, Boston, MA 02115 - USA
[2] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Sao Paulo, SP - Brazil
[3] Harvard Med Sch, Boston, MA - USA
[4] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA
[5] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 - USA
[6] Yonsei Univ, Dept Sport Ind Studies, Exercise Med & Rehabil Lab, Seoul - South Korea
[7] Yonsei Univ, Coll Med, ICONS, Exercise Med Ctr Diabet & Canc Patients, Seoul - South Korea
Total Affiliations: 7
Document type: Journal article
Source: Diabetes/Metabolism Research and Reviews; v. 35, n. 2 FEB 2019.
Web of Science Citations: 0

Background Positive association between resting heart rate (RHR) and risk of type 2 diabetes (T2D) has been documented in several studies. However, whether RHR is an independent predictor of T2D and its potential interaction with other risk factors of T2D remain unclear. Methods We conducted a prospective cohort study of 31 156 men from the Health Professionals Follow-up Study (1992-2012). Cox proportional hazard model was used to examine the association between RHR and T2D risk. We further examined whether this association is modified by known risk factors. Lastly, we conducted a meta-analysis of prospective cohort studies. Results During 505 380 person-years of follow-up, we identified 2338 incident T2D cases. The multivariable-adjusted hazard ratio (HR) comparing the highest vs lowest categories of RHR was 1.69 (95% confidence interval {[}CI], 1.43-2.01). Increase in 10 bpm of RHR was associated with 19% increased risk of T2D in the fully adjusted model (HR, 1.19; 95% CI, 1.14-1.24). The HRs of T2D associated with RHR were stronger among those with normal weight or without hypertension (P interaction < 0.001). Moreover, RHR with other known risk factors cumulatively increased T2D risk. A meta-analysis consistently showed a positive association between RHR and T2D risk (the summary relative risk {[}RR] for highest vs lowest RHR, 1.53; 95% CI, 1.26-1.86, n = 12, the summary RR per 10 bpm increase, 1.17; 95% CI, 1.09-1.26, n = 13). Conclusions High RHR was independently associated with increased risk of T2D. Our findings suggest that RHR, with other known risk factors, could be a useful tool to predict T2D risk. (AU)

FAPESP's process: 16/21390-0 - Burden of cancer attributable to lifestyle risk factors in Brazil
Grantee:Leandro Fórnias Machado de Rezende
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/25614-4 - Physical inactivity and cancer: from evaluation of etiological evidence to public health impact
Grantee:Leandro Fórnias Machado de Rezende
Support type: Scholarships in Brazil - Doctorate