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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antibacterial and anti-biofilm activities of cinnamaldehyde against S. epidermidis

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Albano, Mariana [1] ; Crulhas, Bruno Pereira [2] ; Bergamo Alves, Fernanda Cristina [1] ; Marques Pereira, Ana Flavia [1] ; Murbach Teles Andrade, Bruna Fernanda [1] ; Barbosa, Lidiane Nunes [3] ; Furlanetto, Alessandra [1] ; da Silveira Lyra, Luciana Pupo [1] ; Mores Rall, Vera Lucia [1] ; Fernandes Junior, Ary [1]
Total Authors: 10
[1] Univ Estadual Paulista, Dept Microbiol & Immunol, BR-18618691 Botucatu, SP - Brazil
[2] Univ Estadual Paulista, Dept Chem & Biochem, BR-18618693 Botucatu, SP - Brazil
[3] Univ Paranaense, Anim Sci Postgrad Program, BR-87502210 Curitiba, Parana - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Microbial Pathogenesis; v. 126, p. 231-238, JAN 2019.
Web of Science Citations: 3

The search for new antimicrobial drugs has been necessary due to the increased bacterial resistance to antibiotics currently in use, and natural products play an important role in this field. The aim of this study was to evaluate the in vitro effect of cinnamaldehyde on S. epidermidis strains, biofilm set-up prevention, as well as its effect on pre-established biofilms. The minimum inhibitory concentration (MIC) ranged from 300 to 500 mu g/mL, and the minimum bactericidal concentration (MBC) from 400 to 600 mu g/mL. The biofilm inhibitory concentration and biofilm eradication concentration values were four-fold (clinical isolate) and eight-fold (ATCC strain) greater than the concentration required to inhibit planktonic growth. Sub-inhibitory concentrations of cinnamaldehyde attenuated biofilm formation of S. epidermidis strains on polystyrene microtiter plates. The combination of cinnamaldehyde and linezolid was able to inhibit S. epidermidis with a bactericidal effect. Further investigation of the mechanism of action of cinnamaldehyde revealed its effect on the cell membrane permeability, and confocal laser scanning microscopy (CLSM) images illustrated the impact of cinnamaldehyde in the detachment and killing of existing biofilms. Thereby, our data confirmed the ability of cinnamaldehyde to reduce bacterial planktonic growth of S. epidermidis, inhibiting biofilm formation and eradicating pre-formed biofilm. (AU)

FAPESP's process: 15/14278-6 - The impact of natural compounds in bacteria of clinical interest
Grantee:Ary Fernandes Júnior
Support type: Regular Research Grants