Calcagno, Danielle Q.
[1, 2, 3]
da Silva Mota, Elizangela R.
Maia de Sousa, Stefanie B.
Costa da Silva, Jessica M.
Leal, Mariana F.
Gigek, Carolina O.
Santos, Leonardo C.
Rasmussen, Lucas T.
Assumpcao, Paulo P.
Burbano, Rommel R.
Smith, Marilia A. C.
Total Authors: 12
 Univ Fed Para, Programa Posgrad Quim Med & Modelagem Mol, Belem, PA - Brazil
 Univ Fed Para, Programa Posgrad Oncol & Ciencias Med, Nucleo Pesquisas Oncol, Belem, PA - Brazil
 Univ Fed Para, Saude Oncol, Hosp Univ Joao de Barros Barreto, Belem, PA - Brazil
 Univ Fed Sao Paulo, Disciplina Genet, Sao Paulo, SP - Brazil
 Univ Fed Para, Fac Biotecnol, Belem, PA - Brazil
 Univ Fed Sao Paulo, Dept Patol, Sao Paulo, SP - Brazil
 Hosp Ophir Loyola, Lab Biol Mol, Belem, PA - Brazil
Total Affiliations: 7
Web of Science Citations:
Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative treatment and preventive strategies for cancer. For example, in gastric cancer, cholecalciferol, curcumin, resveratrol, quercetin, garcinol and sodium butyrate are natural regulators of acetylation and deacetylation enzyme activity that exert chemopreventive and anticancer effects. Here, we review the recent findings on histone acetylation in gastric cancer and discuss the effects of nutrients and bioactive compounds on histone acetylation and their potential role in the prevention and treatment of this type of cancer. (AU)