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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives

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Calcagno, Danielle Q. [1, 2, 3] ; Wisnieski, Fernanda [4] ; da Silva Mota, Elizangela R. [1] ; Maia de Sousa, Stefanie B. [2] ; Costa da Silva, Jessica M. [5] ; Leal, Mariana F. [4, 2] ; Gigek, Carolina O. [6, 4] ; Santos, Leonardo C. [4] ; Rasmussen, Lucas T. [4] ; Assumpcao, Paulo P. [2] ; Burbano, Rommel R. [2, 7] ; Smith, Marilia A. C. [4]
Total Authors: 12
[1] Univ Fed Para, Programa Posgrad Quim Med & Modelagem Mol, Belem, PA - Brazil
[2] Univ Fed Para, Programa Posgrad Oncol & Ciencias Med, Nucleo Pesquisas Oncol, Belem, PA - Brazil
[3] Univ Fed Para, Saude Oncol, Hosp Univ Joao de Barros Barreto, Belem, PA - Brazil
[4] Univ Fed Sao Paulo, Disciplina Genet, Sao Paulo, SP - Brazil
[5] Univ Fed Para, Fac Biotecnol, Belem, PA - Brazil
[6] Univ Fed Sao Paulo, Dept Patol, Sao Paulo, SP - Brazil
[7] Hosp Ophir Loyola, Lab Biol Mol, Belem, PA - Brazil
Total Affiliations: 7
Document type: Review article
Source: Epigenomics; v. 11, n. 3, p. 349-362, FEB 2019.
Web of Science Citations: 2

Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative treatment and preventive strategies for cancer. For example, in gastric cancer, cholecalciferol, curcumin, resveratrol, quercetin, garcinol and sodium butyrate are natural regulators of acetylation and deacetylation enzyme activity that exert chemopreventive and anticancer effects. Here, we review the recent findings on histone acetylation in gastric cancer and discuss the effects of nutrients and bioactive compounds on histone acetylation and their potential role in the prevention and treatment of this type of cancer. (AU)

FAPESP's process: 16/19953-6 - Epigenetically modulated genes may constitute therapeutic targets in patients with gastric cancer?
Grantee:Fernanda Wisnieski
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/25562-0 - Gastric cancer molecular and functional approaches in the Brazilian population
Grantee:Marilia de Arruda Cardoso Smith
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/14768-5 - Nontraumatic orthopedic conditions of shoulder: genetic and molecular aspects
Grantee:Mariana Ferreira Leal
Support type: Scholarships in Brazil - Young Researchers