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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of -alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise

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da Silva, Rafael Pires [1, 2] ; de Oliveira, Luana Farias [1, 2] ; Saunders, Bryan [1, 2, 3] ; Kratz, Caroline de Andrade [1, 2] ; Painelli, Vitor de Salles [1, 2] ; Silva, Vinicius da Eira [1, 2] ; Bouzas Marins, Joao Carlos [4] ; Franchini, Emerson [5] ; Gualano, Bruno [1, 2, 6] ; Artioli, Guilherme Giannini [1, 2, 7]
Total Authors: 10
[1] Univ Sao Paulo, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med FMUSP, Appl Physiol & Nutr Res Grp, Rheumatol Div, Sch Phys Educ & Sport, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med FMUSP, Inst Orthoped & Traumatol, Sao Paulo, SP - Brazil
[4] Univ Fed Vicosa, Dept Phys Educ, Vicosa, MG - Brazil
[5] Univ Sao Paulo, Sch Phys Educ & Sport, Dept Sport, Sao Paulo - Brazil
[6] Univ Sao Paulo, Div Rheumatol, Fac Med FMUSP, Sao Paulo, SP - Brazil
[7] Ave Prof Mello Moraes 65 Butanta, BR-05508030 Sao Paulo, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Amino Acids; v. 51, n. 1, p. 83-96, JAN 2019.
Web of Science Citations: 2

The effects of -alanine (BA) and sodium bicarbonate (SB) on energy metabolism during work-matched high-intensity exercise and cycling time-trial performance were examined in 71 male cyclists. They were randomised to receive BA+placebo (BA, n=18), placebo+SB (SB, n=17), BA+SB (BASB, n=19), or placebo+placebo (PLA, n=18). BA was supplemented for 28days (6.4gday(-1)) and SB (0.3gkg(-1)) ingested 60min before exercise on the post-supplementation trial. Dextrose and calcium carbonate were placebos for BA and SB, respectively. Before (PRE) and after (POST) supplementation, participants performed a high-intensity intermittent cycling test (HICT-110%) consisting of four 60-s bouts at 110% of their maximal power output (60-s rest between bouts). The estimated contribution of the energy systems was calculated for each bout in 39 of the participants (BA: n=9; SB: n=10; BASB: n=10, PLA: n=10). Ten minutes after HICT-110%, cycling performance was determined in a 30-kJ time-trial test in all participants. Both groups receiving SB increased estimated glycolytic contribution in the overall HICT-110%, which approached significance (SB: +23%, p=0.068 vs. PRE; BASB: +18%, p=0.059 vs. PRE). No effects of supplementation were observed for the estimated oxidative and ATP-PCr systems. Time to complete 30 kJ was not significantly changed by any of the treatments, although a trend toward significance was shown in the BASB group (p=0.06). We conclude that SB, but not BA, increases the estimated glycolytic contribution to high-intensity intermittent exercise when total work done is controlled and that BA and SB, either alone or in combination, do not improve short-duration cycling time-trial performance. (AU)

Grantee:Rafael Pires da Silva
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
Grantee:Guilherme Giannini Artioli
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/04806-0 - Effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations
Grantee:Vitor de Salles Painelli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/14746-4 - Carnosine metabolism in skeletal muscle: a multi-approach study
Grantee:Bruno Gualano
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Research Grants - Young Investigators Grants