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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity

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Santos, Beatriz Mendes [1, 2] ; Bezerra-Souza, Adriana [1] ; Aragaki, Sonia [3] ; Rodrigues, Eliana [4] ; Umehara, Eric [5] ; Ghilardi Lago, Joao Henrique [5] ; Laurenti, Marcia Dalastra [6, 7] ; Ribeiro, Susan Pereira [8] ; Domingues Passero, Luiz Felipe [1, 2]
Total Authors: 9
[1] Sao Paulo State Univ UNESP, Inst Biosci, Praca Infante Dom Henrique S-N, BR-11330900 Sao Vicente, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Adv Studies Ocean, Ave Joao Francisco Bensdorp 1178, BR-11350011 Sao Vicente, SP - Brazil
[3] Inst Bot Estado Sao Paulo, Nucleo Pesquisa Curadoria Herbario, Ave Miguel Stefano 3687, BR-04301902 Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo UNIFESP, Inst Environm Sci Chem & Pharmaceut, Ctr Ethnobot & Ethnopharmacol Studies CEE, Sao Paulo - Brazil
[5] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil
[6] Univ Sao Paulo, Sch Med, Lab Pathol Infect Dis, Sao Paulo, SP - Brazil
[7] Ave Dr Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[8] Case Western Reserve Univ, Dept Pathol, 2103 Cornell Rd, Room 5503, Cleveland, OH 44106 - USA
Total Affiliations: 8
Document type: Journal article
Source: Evidence-based Complementary and Alternative Medicine; 2019.
Web of Science Citations: 0

Leishmaniasis is an infectious disease caused by a protozoan belonging to Leishmania genus. Different clinical outcomes can be observed depending on the parasite species and patient's health condition. The outcomes can range from single cutaneous lesions to lethal visceral form. The treatment of all forms of leishmaniasis is based on pentavalent antimonials, and, in some cases, the second-line drug, amphotericin B, is used. Beside the toxicity of both classes of drugs, in some areas of the world, parasites are resistant to antimonial. These detrimental features make fundamental the discovery and characterization of new drugs or plant extracts with leishmanicidal effects. Brazil is a well-known country for its biodiversity. Additionally, the common knowledge inherited for generations in small villages makes Brazil a source of new information and resources for the discovery and development of new drugs. Based on ethnopharmacology, elderlies were interviewed about plants they commonly used for skin diseases and infections. Five native plants from Atlantic forest were indicated; EtOH and n-hexane extracts were prepared with the vegetative organs of the plants and assayed against promastigote and amastigote forms of L. (L.) amazonensis. The major molecules of each extract were detected using qualitative nuclear magnetic resonance. Among all tested extracts, the n-hexane extract from the leave of Eugenia uniflora (Myrtaceae), enriched in myricitrin and quercitrin flavonoids, was the most effective against L. (L.) amazonensis amastigotes. This data supports the ethnopharmacology approach as a successful tool for the discovery of new drugs with leishmanicidal effects. (AU)

FAPESP's process: 18/07885-1 - Biomolecules from plant species of remnant areas of the Atlantic Forest and Cerrado to treat neglected tropical diseases - chemical and pharmacological aspects
Grantee:João Henrique Ghilardi Lago
Support type: BIOTA-FAPESP Program - Regular Research Grants