| Full text | |
| Author(s): |
Ramos do Prado, Samira Bernardino
[1]
;
Shiga, Tania Misuzu
[1]
;
Harazono, Yosuke
[2, 3, 4, 5]
;
Hogan, Victor A.
[2, 3, 4]
;
Raz, Avraham
[2, 3, 4]
;
Carpita, Nicholas C.
[6]
;
Fabi, Joao Paulo
[7, 1, 8]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP - Brazil
[2] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI - USA
[3] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 - USA
[4] Karmanos Canc Inst, B, Detroit, MI - USA
[5] Tokyo Med & Dent Univ, Dept Maxillofacial Surg, Bunkyo Ku, Tokyo - Japan
[6] Purdue Univ, Dept Bot & Plant Pathol, W Lafayette, IN 47907 - USA
[7] Univ Sao Paulo, Food & Nutr Res Ctr NAPAN, Sao Paulo, SP - Brazil
[8] Sao Paulo Res Fdn, Res Innovat & Disseminat Cts, CEPID FAPESP, Food Res Ctr FoRC, Sao Paulo, SP - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Carbohydrate Polymers; v. 211, p. 141-151, MAY 1 2019. |
| Web of Science Citations: | 4 |
| Abstract | |
While chemically and thermally modified citrus pectin (MCP) has already been studied for health benefits, it is unknown how size-fractionated oligo-and polysaccharides differentially affect cancer cell behavior. We produced thermally MCP and fractionated it by molecular size to evaluate the effect these polymers have on cancer cells. MCP30/10 (between 30 and 10 kDa) had more esterified homogalacturonans (HG) and fewer rhamnogalacturonans (RG-I) than MCP and MCP30 (higher than 30 kDa), while MCP10/3 (between 10 and 3 kDa) showed higher amounts of type I arabinogalactans (AGI) and lower amounts of RG-I. MCP3 (smaller than 3 kDa) presented less esterified HG and the lowest amount of AGI and RG-I. Our data indicate that the enrichment of deesterified HG oligomers and the AGI and RG-I depletions in MCP3, or the increase of AGI and loss of RGI in MCP30/10, enhance the anticancer behaviors by inhibiting migration, aggregation, and proliferation of cancer cells. (AU) | |
| FAPESP's process: | 15/01004-5 - Multi-User Equipment approved in grant 2012/23970-2: QuantStudio 7 flex Real-Time PCR system, 96-well fast, laptop (catalog #: 4485698) |
| Grantee: | Joao Paulo Fabi |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 13/07914-8 - FoRC - Food Research Center |
| Grantee: | Bernadette Dora Gombossy de Melo Franco |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 12/23970-2 - Biological changes of papaya pectins with possible benefits to human health |
| Grantee: | Joao Paulo Fabi |
| Support Opportunities: | Research Grants - Young Investigators Grants |