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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The evolution, distribution and diversity of endogenous circoviral elements in vertebrate genomes

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Author(s):
Dennis, Tristan P. W. [1] ; de Souza, William Marciel [2, 1] ; Marsile-Medun, Soledad [1, 3] ; Singer, Joshua B. [1] ; Wilson, Sam J. [1] ; Gifford, Robert J. [1]
Total Authors: 6
Affiliation:
[1] Univ Glasgow, MRC, Ctr Virus Res, 464 Bearsden Rd, Glasgow, Lanark - Scotland
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, Ribeirao Preto - Brazil
[3] Agrocampus Ouest, 65 Rue St Brieuc, F-35000 Rennes - France
Total Affiliations: 3
Document type: Journal article
Source: VIRUS RESEARCH; v. 262, n. SI, p. 15-23, MAR 2019.
Web of Science Citations: 2
Abstract

Circoviruses (family Circoviridae) are small, non-enveloped viruses that have short, single-stranded DNA genomes. Circovirus sequences are frequently recovered in metagenomic investigations, indicating that these viruses are widespread, yet they remain relatively poorly understood. Endogenous circoviral elements (CVe) are DNA sequences derived from circoviruses that occur in vertebrate genomes. CVe are a useful source of information about the biology and evolution of circoviruses. In this study, we screened 362 vertebrate genome assemblies in silica to generate a catalog of CVe loci. We identified a total of 179 CVe sequences, most of which have not been reported previously. We show that these CVe loci reflect at least 19 distinct germline integration events. We determine the structure of CVe loci, identifying some that show evidence of potential functionalization. We also identify orthologous copies of CVe in snakes, fish, birds, and mammals, allowing us to add new calibrations to the timeline of circovirus evolution. Finally, we observed that some ancient CVe group robustly with contemporary circoviruses in phylogenies, with all sequences within these groups being derived from the same host class or order, implying a hitherto underappreciated stability in circovirus-host relationships. The openly available dataset constructed in this investigation provides new insights into circovirus evolution, and can be used to facilitate further studies of circoviruses and CVe. (AU)

FAPESP's process: 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing
Grantee:William Marciel de Souza
Support type: Scholarships in Brazil - Post-Doctorate