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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

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Author(s):
Locilento, Danilo A. [1, 2] ; Mercante, Luiza A. [2, 3] ; Andre, Rafaela S. [2] ; Mattoso, Luiz H. C. [2, 3] ; Luna, Genoveva L. F. [4] ; Brassolatti, Patricia [4] ; Anibal, Fernanda de F. [4] ; Correa, Daniel S. [1, 2]
Total Authors: 8
Affiliation:
[1] Fed Univ Sao Carlos UFSCar, Ctr Exact Sci & Technol, Dept Chem, PPGQ, BR-13565905 Sao Carlos, SP - Brazil
[2] Embrapa Instrumentacao, Nanotechnol Natl Lab Agr LNNA, BR-13560970 Sao Carlos, SP - Brazil
[3] Fed Univ Sao Carlos UFSCar, Ctr Exact Sci & Technol, Dept Mat Engn, PPG CEM, BR-13565905 Sao Carlos, SP - Brazil
[4] Univ Fed Sao Carlos UFSCar, Dept Morphol & Pathol, Lab Parasitol, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Nanomaterials; 2019.
Web of Science Citations: 1
Abstract

The development of nanofibrous membranes with tunable wettability, degradation, and biocompatibility is highly keen for biomedical applications, including drug delivery and wound dressing. In this study, biocompatible and biodegradable nanofibrous membranes with antioxidant properties were successfully prepared by the electrospinning technique. The membranes were developed using polylactic acid (PLA) and polyethylene oxide (PEO) as the matrix, with the addition of grape seed extract (GSE), a rich source of natural antioxidants. The nanofibrous membranes were thoroughly characterized both from the materials and from the biocompatibility point of view. PLA and PLA/PEO nanofibers showed high encapsulation efficiency, close to 90%, while the encapsulated GSE retained its antioxidant capacity in the membranes. In vitro release studies showed that GSE diffuses from PLA/GSE and PLA/PEO/GSE membranes in a Fickian diffusion manner, whose experimental data were well fitted using the Korsmeyer-Peppas model. Furthermore, a higher controlled release of GSE was observed for the PLA/PEO/GSE membrane. Moreover, culturing experiments with human foreskin fibroblast (HFF1) cells demonstrated that all samples are biocompatible and showed that the GSE-loaded PLA/PEO nanofibrous membranes support better cell attachment and proliferation compared to the PLA/GSE nanofibrous membranes, owing to the superior hydrophilicity. In summary, the results suggested that the GSE-loaded membranes are a promising topical drug delivery system and have a great potential for wound dressing applications. (AU)

FAPESP's process: 16/23793-4 - Development of nanostructured sensor aiming the detection of volatile compounds for food quality indicators
Grantee:Rafaela da Silveira Andre
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/12174-4 - Development of hybrid polymer nanofibers for agricultural applications
Grantee:Daniel Souza Corrêa
Support type: Regular Research Grants