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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioinformatics applied to biotechnology: A review towards bioenergy research

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de Carvalho, L. M. [1] ; Borelli, G. [1] ; Camargo, A. P. [1] ; de Assis, M. A. [1] ; de Ferraz, S. M. F. [1] ; Fiamenghi, M. B. [1] ; Jose, J. [1] ; Mofatto, L. S. [1] ; Nagamatsu, S. T. [1] ; Persinoti, G. F. [2] ; Silva, N. V. [1] ; Vasconcelos, A. A. [1] ; Pereira, G. A. G. [1] ; Carazzolle, M. F. [1]
Total Authors: 14
[1] Univ Estadual Campinas, Lab Genom & BioEnergia, Dept Genet & Evolucao Microbiol & Imunol, BR-13083970 Campinas, SP - Brazil
[2] CNPEM, Lab Nacl Ciencia Tecnol Bioetanol CTBE, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: BIOMASS & BIOENERGY; v. 123, p. 195-224, APR 2019.
Web of Science Citations: 1

The ever-increasing demand for energy, along with worldwide policies aiming sustainability, resulted in an escalation of research projects focusing on alternative routes for energy production. Among the available options, microorganism fermentation using lignocellulosic biomass as a carbon source to generate bioproducts is considered a promising technology for industrial applications, with potential to replace several sources of non-renewable origin that are widely used today. In this context, various new industrial processes have been developed, such as the second-generation ethanol technology, which allows bioethanol production from lignocellulosic biomass by genetically modified microorganisms. In recent years, fields in biotechnology were mainly driven by advances in molecular biology and genetic engineering tools, which culminated in the `omics' revolution. Recent developments in DNA sequencing and liquid/mass spectrometry technologies, supported by research in bioinformatics and high-performance computing, allowed the identification of new organisms and metabolic processes, expanding the human knowledge about biological systems. The result of this newly gained understanding is the ability to perform genetic modifications focusing on the obtention of interesting phenotypes with increased productivity and resistance or the synthesis of new compounds that were previously produced using non-renewable routes. In this context, this review presents the bioinformatics workflows and applications of `omics' approaches in biotechnological research, focusing on genomics, metagenomics, phylogenomics, transcriptomics, proteomics, metabolomics and their integration to enable a holistic overview of biological systems. (AU)

FAPESP's process: 16/02792-0 - Identification of enzymes with potential for biotechnological applications in a Trichoderma sp fungus
Grantee:Michelle Alexandrino de Assis
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/26905-2 - Bioinformatic analysis of QTLs mapping by high-throughput sequencing to identification of robustness mechanisms of industrial yeast
Grantee:Sheila Tiemi Nagamatsu
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/05379-6 - Analysis of the lincRNA transcriptome in the accessory olfactory system
Grantee:Antônio Pedro de Castello Branco da Rocha Camargo
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/08293-7 - CCES - Center for Computational Engineering and Sciences
Grantee:Munir Salomao Skaf
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 15/06263-9 - Development of methods of analysis and data integration of omics applied to the construction of industrial yeasts for second generation bioethanol production
Grantee:Lucas Miguel de Carvalho
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/13015-7 - Investigation of global transcriptional alterations in the Theobroma cacao x Moniliophthora perniciosa pathosystem during the progression of Witches Broom Disease of cacao
Grantee:Adrielle Ayumi de Vasconcelos
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/07008-8 - Characterization of novel putative xylose transporters of Spathaspora passalidarum and heterologous expression in an industrial strain of Saccharomyces cerevisiae
Grantee:Mateus Bernabe Fiamenghi
Support type: Scholarships in Brazil - Scientific Initiation