| Full text | |
| Author(s): Show less - |
de Souza, Francis Ribeiro
[1]
;
Dos Santos, Marcelo Rodrigues
[1]
;
Porello, Rafael Armani
[1]
;
Peixoto da Fonseca, Guilherme Wesley
[1]
;
Carrari Sayegh, Ana Luiza
[1]
;
Lima, Thais Pinheiro
[1]
;
Ferreira, Fabiana Dias
[2]
;
de Oliveira, Tiago Franco
[3]
;
Yonamine, Mauricio
[4]
;
Takayama, Liliam
[5]
;
Rodrigues Pereira, Rosa Maria
[5]
;
Negrao, Carlos Eduardo
[1]
;
Passarelli, Marisa
[2, 6]
;
Rochitte, Carlos Eduardo
[1]
;
de Nazare Nunes Alves, Maria Janieire
[1]
Total Authors: 15
|
| Affiliation: | [1] Univ Sao Paulo, Inst Coracao InCor, Hosp Clin, Fac Med, Sao Paulo - Brazil
[2] Univ Sao Paulo, Hosp Clin, Lab Lipides LIM 10, Fac Med, Sao Paulo - Brazil
[3] Univ Fed Ciencias Saude Porto Alegre, Dept Farmacociencias, Porto Alegre, RS - Brazil
[4] Univ Sao Paulo, Dept Anal Clin & Toxicol, Fac Ciencias Farmaceut, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Hosp Clin, Lab Metab Osseo, Fac Med, Sao Paulo - Brazil
[6] Univ Nove Julho, Programa Posgrad Med, Sao Paulo, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | ATHEROSCLEROSIS; v. 283, p. 100-105, APR 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Background and aims: Anabolic androgenic steroids (AAS) have been associated with coronary artery disease (CAD). AAS abuse leads to a remarkable decrease in high-density lipoprotein (HDL) plasma concentration, which could be a key factor in the atherosclerotic process. Moreover, not only the concentration of HDL, but also its functionality, plays a pivotal role in CAD. We tested the functionality of HDL by cholesterol efflux and antioxidant capacity. We also evaluated the prevalence of CAD in AAS users. Methods: Twenty strength-trained AAS users (AASU) age 29 +/- 5 yr, 20 age-matched strength-trained AAS nonusers (AASNU), and 10 sedentary controls (SC) were enrolled in this cross-sectional study. Functionality of HDL was evaluated by C-14-cholesterol efflux and the ability of HDL in inhibiting LDL oxidation. Coronary artery was evaluated with coronary computed tomography angiography. Results: Cholesterol efflux was lower in AASU compared with AASNU and SC (20 vs. 23 vs. 24%, respectively, p < 0.001). However, the lag time for LDL oxidation was higher in AASU compared with AASNU and SC (41 vs 13 vs 11 min, respectively, p < 0.001). We found at least 2 coronary arteries with plaques in 25% of AASU. None of the AASNU and SC had plaques. The time of AAS use was negatively associated with cholesterol efflux. Conclusions: This study indicates that AAS abuse impairs the cholesterol efflux mediated by HDL. Long-term AAS use seems to be correlated with lower cholesterol efflux and early subclinical CAD in this population. (AU) | |
| FAPESP's process: | 12/10527-3 - Impact of self-administrating anabolic androgenic on cardiovascular system |
| Grantee: | Maria Janieire de Nazaré Nunes Alves |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/24306-0 - The effect of NEPRIlysin (LCZ696) on EXercise TOLerance, muscle vasodilatation, muscle strength and body composition in patients with Heart Failure - NEPRIExTol-HF Trial |
| Grantee: | Marcelo Rodrigues dos Santos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |