Detecting ovarian cancer using extracellular vesicles: progress and possibilities

Author(s)

Carollo, Emanuela ^[1] ; Paris, Bianca ^[1] ; Samuel, Priya ^[1] ; Pantazi, Paschalia ^[1] ; Bartelli, Thais Fernanda ^{[1, 2]} ; Dias-Neto, Emmanuel ^{[2, 3]} ; Brooks, Susan Ann ^[1] ; Pink, Ryan Charles ^[1] ; Carter, David Raul Francisco ^[1]

Affiliation

^[1] Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Oxford OX3 0BP - England

^[2] AC Camargo Canc Ctr, Lab Med Genom, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Inst Psiquiatria, Fac Med, Lab Neurosci Alzira Denise Hertzog Silva LIM 27, Sao Paulo, SP - Brazil

• Document type: Review article
• Source: BIOCHEMICAL SOCIETY TRANSACTIONS; v. 47, n. 1, p. 295-304, FEB 28 2019.
• Web of Science Citations: 2

Abstract

Ovarian cancer (OC) is the deadliest gynecological malignancy. Most patients are diagnosed when they are already in the later stages of the disease. Earlier detection of OC dramatically improves the overall survival, but this is rarely achieved as there is a lack of clinically implemented biomarkers of early disease. Extracellular vesicles (EVs) are small cell-derived vesicles that have been extensively studied in recent years. They contribute to various aspects of cancer pathology, including tumor growth, angiogenesis and metastasis. EVs are released from all cell types and the macromolecular cargo they carry reflects the content of the cells from which they were derived. Cancer cells release EVs with altered cargo into biofluids, and so, they represent an excellent potential source of novel biomarkers for the disease. In this review, we describe the latest developments in EVs as potential biomarkers for earlier detection of OC. The field is still relatively young, but many studies have shown that EVs and the cargo they carry, including miRNAs and proteins, can be used to detect OC. They could also give insights into the stage of the disease and predict the likely therapeutic outcome. There remain many challenges to the use of EVs as biomarkers, but, through ongoing research and innovation in this exciting field, there is great potential for the development of diagnostic assays in the clinic that could improve patient outcome. (AU)

• FAPESP's process: 15/50257-3 - Extracellular vesicles and non-cellular RNA: roles in health and neglected tropical diseases | São Paulo - SP
• Grantee: Emmanuel Dias-Neto
• Support type: Research Grants - Organization of Scientific Meeting
• FAPESP's process: 14/26897-0 - Epidemiology and genomics of gastric adenocarcinomas in Brazil
• Grantee: Emmanuel Dias-Neto
• Support type: Research Projects - Thematic Grants