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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of Leishmania (Viannia) braziliensis infection on the attractiveness of BALB/c mice to Nyssomyia neivai (Diptera: Psychodidae)

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Author(s):
da Rocha Silva, Flavia Benini [1] ; Miguel, Danilo Ciccone [2] ; Machado, Vicente Estevam [1] ; Cruz Oliveira, Wanderson Henrique [1] ; Goulart, Thais Marchi [2] ; Tosta, Christiann Davis [3] ; Pinheiro, Hildete Prisco [4] ; Pinto, Mara Cristina [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, Campus Araraquara, Araraquara, SP - Brazil
[2] Univ Estadual Campinas UNICAMP, Dept Biol Anim, Campinas, SP - Brazil
[3] Inst Fed Educ Ciencia & Tecnol Sao Paulo IFSP, Campus Matao, Matao, SP - Brazil
[4] Univ Estadual Campinas UNICAMP, Dept Estat, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PLoS One; v. 14, n. 4 APR 1 2019.
Web of Science Citations: 0
Abstract

Background Phlebotomine sand flies are vectors for several pathogens, with Leishmania being the most important. In Brazil, the main aetiological agent of American cutaneous leishmaniasis (ACL) is Leishmania (Viannia) braziliensis, and Nyssomyia neivai is one of its main vectors in Sao Paulo state and other areas of South America. Similar to other haematophagous insects, sand flies use volatile compounds called kairomones to locate their hosts for blood meals. A possible increase in the attractiveness of hosts infected with Leishmania infantum to their vectors has been demonstrated. In the present study, we aimed to investigate whether L. braziliensis-infected hosts present higher attractiveness to Ny. neivai and to identify differences in the volatile compounds released by infected and uninfected mice. Results Behavioural experiments in which sand fly females directly fed on infected or uninfected mice showed no significant differences in the attractiveness of the mice or the blood volume ingested. Y-tube olfactometer bioassays also revealed no significant differences in the attractiveness of these hosts to Ny. neivai. No differences were observed in the profiles of the volatile compounds released by the two groups of mice. However, PCA and cluster analysis were able to classify the 31 identified compounds into three clusters according to their abundances. This classification showed a possible role for individual variation in the absence of differences in volatile profiles and attractiveness between infected and uninfected mice. Conclusion In this first cross-sectional study with an aetiological agent of ACL, there were no statistically significant differences in the attractiveness of infected hosts to their vector. (AU)

FAPESP's process: 12/23832-9 - Biological aspects of Nyssomyia neivai (Diptera: Psychodidae) and improvements in laboratory colonization techniques
Grantee:Mara Cristina Pinto
Support type: Regular Research Grants
FAPESP's process: 14/21129-4 - The role of fatty acid-binding proteins in the macrophage infection by Leishmania: a potential target for new drugs against leishmaniasis
Grantee:Danilo Ciccone Miguel
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/21100-9 - Study on attractiveness of infected host with Leishmania (Viannia) braziliensis (Kinetoplastida: Trypanosomatidae) to Nyssomyia neivai (Diptera: Psychodidae)
Grantee:Flávia Benini da Rocha Silva
Support type: Scholarships in Brazil - Master